Cognition and Behaviour in Childhood Epilepsy, Lagae, Chapter 11 cover

Cognition and Behaviour in Childhood Epilepsy – Chapter 11: Infantile Spasms: Early Treatment may Improve Neurodevelopmental Outcomes (ebook)

Product Type: PDF (Sub-Section of Book)

Series: Clinics in Developmental Medicine

Edition: 1st

Publication date: May 2017

Page count: 15

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Chapter 11 – Infantile Spasms: Early Treatment may Improve Neurodevelopmental Outcomes

Infantile spasms is the term given to the most common epilepsy syndrome with onset in infancy. It has been the focus of many studies, in part because of the high probability of children with infantile spasms having poor neurodevelopmental outcomes. In considering the possible effects of infantile spasms upon cognition and behaviour, both during the period in which clinical epileptic spasms are occurring and during subsequent life, it is essential to consider several factors and relationships related to their pathophysiology. The most important of these are (1) the nature of the probable underlying cause (or aetiology) for the infantile spasms; (2) the effects that any identified aetiology might have upon the proneness to infantile spasms or other forms of epilepsy, and upon longer term prospects for development; and (3) the causal relationships that are known to exist or might exist between aetiology, the epileptic spasms, and neurodevelopmental outcomes. It is also important to consider questions related to treatment interventions, the key questions being (1) which treatment interventions are most likely to lead to the best cognitive and behavioural outcomes and (2) what is the optimal timing for these interventions.

About the book

For many parents, cognitive and behavioral comorbidities, such as ADHD, autism and intellectual disability, are the real burden of childhood epilepsy. This title offers concrete guidance and treatment strategies for childhood epilepsy in general, and for the comorbidities associated with each epilepsy syndrome and their pathophysiology. The book is written by experts in the field with an important clinical experience, while chapters by clinical neuropsychologists provide a strong theoretical background.

Readership: Epileptologists, Paediatric Neurologists, Paediatricians and Neuropsychologists.

Andrew Lux (Author) Lieven Lagae (Editor)

Lieven Lagae is Professor of Paediatric Neurology at the University of Leuven, Belgium (KUL), Head of the Paediatric Neurology Department of the KUL University Hospitals, and Director of the Childhood Epilepsy Program at the KUL University Hospitals. He is the current President of the European Pediatric Neurology Society and serves as an elected Board Member of the International Child Neurology Association (ICNA). From 2004 to 2015 he was the Editor-in-Chief of the European Journal of Paediatric Neurology. His research interests include translational research in zebrafish models of epilepsy, new antiepileptic drugs for childhood epilepsy, brain stimulation and preventive treatment of epilepsy in tuberous sclerosis.

  • Full book contents
  • AUTHORS’ APPOINTMENTS
  • PREFACE
  • 1. COGNITIVE DIFFICULTIES IN CHILDREN WITH EPILEPSY: SOURCES AND IMPLICATIONS
  • ANNE T BERG
  • 2. INTRODUCTORY REMARKS ON NEUROPSYCHOLOGICAL TESTING IN CHILDHOOD EPILEPSY
  • AGATHE LAURENT, FAUSTINE ILSKI-LECOANET AND ALEXIS ARZIMANOGLOU
  • 3. BEHAVIOURAL PROBLEMS IN CHILDHOOD EPILEPSY
  • MELISSA FILIPPINI AND GIUSEPPE GOBBI
  • 4. THE INTERACTION BETWEEN CHILDHOOD-ONSET EPILEPSY AND COGNITON: LONG-TERM FOLLOW UP
  • PETER CAMFIELD AND CAROL CAMFIELD
  • 5. USE OF FUNTIONAL IMAGING TO STUDY COGNITIVE FUNCTIONS
  • MADISON M BERL AND LEIGH N SEPETA
  • 6. DISENTANGLING THE ROLE OF SEIZURES AND EEG ABNORMALITIES IN THE PATHOPHYSIOLOGY OF COGNITIVE DYSFUNCTION
  • JONATHAN K KLEEN AND GREGORY L HOLMES
  • 7. CHRONIC COGNITIVE EFFECTS OF ANTIEPILEPTIC DRUGS IN CHILDHOOD EPILEPSY
  • ALBERT P ALDENKAMP, WILLEM LAVRIJSSEN AND DOMINIQUE IJFF
  • 8. OUTCOME AFTER NEONATAL SEIZURES
  • RENÉE A SHELLHAAS AND COURTNEY J WUSTHOFF
  • 9. “BENIGN” CHILDHOOD EPILEPSY SYNDROMES: WHY DO SOME PRESENT WITH LEARNING PROBLEMS?
  • STÉPHANE AUVIN
  • 10. “BENIGN” INFANTILE EPILEPSIES: IMPACT ON LATER COGNITION AND BEHAVIOUR
  • FEDERICO VIGEVANO AND ROMINA MOAVERO
  • 11. INFANTILE SPASMS: EARLY TREATMENT MAY IMPROVE NEURODEVELOPMENTAL OUTCOMES
  • ANDREW LUX
  • 12. DRAVET SYNDROME: MORE THAN SEIZURES
  • EMMA LOSITO AND RIMA NABBOUT
  • 13. THE EPILEPTIC SYNDROMES WITH CONTINUOUS SPIKES AND WAVES DURING SLOW-WAVE SLEEP
  • PATRICK VAN BOGAERT AND XAVIER DE TIÉGE
  • 14. GLOBAL PROGNOSIS AND NEUROPSYCHOLOGICAL OUTCOME OF LENNOX–GASTAUT SYNDROME
  • ALEXIS ARZIMANOGLOU, ELENI PANAGIOTAKAKI AND ALIA RAMIREZ CAMACHO
  • 15. COGNITIVE AND BEHAVIOURAL OUTCOMES AFTER EPILEPSY SURGERY IN CHILDREN
  • MONIQUE MJ VAN SCHOONEVELD, KEES PJ BRAUN AND J HELEN CROSS