Cognition and Behaviour in Childhood Epilepsy, Lagae, Chapter 13 cover

Cognition and Behaviour in Childhood Epilepsy – Chapter 13: The Epileptic Syndromes with Continuous Spikes and Waves during Slow-Wave Sleep (ebook)

Product Type: PDF (Sub-Section of Book)

Series: Clinics in Developmental Medicine

Edition: 1st

Publication date: May 2017

Page count: 12

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Chapter 13 – The Epileptic Syndromes with Continuous Spikes and Waves during Slow-Wave Sleep

In 1957, Landau and Kleffner (1957) reported children with normal early language development who became aphasic after the onset of epileptic seizures and had bilateral temporal interictal epileptiform discharges (IEDs) on EEG. The authors suspected that persistent convulsive discharges resulted in the functional ablation of brain areas concerned with linguistic communication. The language disturbance was further characterized as auditory verbal agnosia, that is, the inability to decode phonemes despite intact peripheral hearing mechanisms, leading to a severe expressive and receptive verbal deficit. Observations of language regression without clinical seizures were further reported. Longitudinal follow-up of these children showed that the seizures as well as the EEG abnormalities remit at adolescence. The Landau–Kleffner syndrome (LKS) was recognized by the International League Against Epilepsy (ILAE) as synonymous with acquired epileptic aphasia to be classified among the epilepsies and syndromes of childhood undetermined whether focal or generalized.

About the book

For many parents, cognitive and behavioral comorbidities, such as ADHD, autism and intellectual disability, are the real burden of childhood epilepsy. This title offers concrete guidance and treatment strategies for childhood epilepsy in general, and for the comorbidities associated with each epilepsy syndrome and their pathophysiology. The book is written by experts in the field with an important clinical experience, while chapters by clinical neuropsychologists provide a strong theoretical background.

Readership: Epileptologists, Paediatric Neurologists, Paediatricians and Neuropsychologists.

Patrick Van Bogaert and Xavier De Tiège (Authors) Lieven Lagae (Editor)

Lieven Lagae is Professor of Paediatric Neurology at the University of Leuven, Belgium (KUL), Head of the Paediatric Neurology Department of the KUL University Hospitals, and Director of the Childhood Epilepsy Program at the KUL University Hospitals. He is the current President of the European Pediatric Neurology Society and serves as an elected Board Member of the International Child Neurology Association (ICNA). From 2004 to 2015 he was the Editor-in-Chief of the European Journal of Paediatric Neurology. His research interests include translational research in zebrafish models of epilepsy, new antiepileptic drugs for childhood epilepsy, brain stimulation and preventive treatment of epilepsy in tuberous sclerosis.

  • Full book contents
  • AUTHORS’ APPOINTMENTS
  • PREFACE
  • 1. COGNITIVE DIFFICULTIES IN CHILDREN WITH EPILEPSY: SOURCES AND IMPLICATIONS
  • ANNE T BERG
  • 2. INTRODUCTORY REMARKS ON NEUROPSYCHOLOGICAL TESTING IN CHILDHOOD EPILEPSY
  • AGATHE LAURENT, FAUSTINE ILSKI-LECOANET AND ALEXIS ARZIMANOGLOU
  • 3. BEHAVIOURAL PROBLEMS IN CHILDHOOD EPILEPSY
  • MELISSA FILIPPINI AND GIUSEPPE GOBBI
  • 4. THE INTERACTION BETWEEN CHILDHOOD-ONSET EPILEPSY AND COGNITON: LONG-TERM FOLLOW UP
  • PETER CAMFIELD AND CAROL CAMFIELD
  • 5. USE OF FUNTIONAL IMAGING TO STUDY COGNITIVE FUNCTIONS
  • MADISON M BERL AND LEIGH N SEPETA
  • 6. DISENTANGLING THE ROLE OF SEIZURES AND EEG ABNORMALITIES IN THE PATHOPHYSIOLOGY OF COGNITIVE DYSFUNCTION
  • JONATHAN K KLEEN AND GREGORY L HOLMES
  • 7. CHRONIC COGNITIVE EFFECTS OF ANTIEPILEPTIC DRUGS IN CHILDHOOD EPILEPSY
  • ALBERT P ALDENKAMP, WILLEM LAVRIJSSEN AND DOMINIQUE IJFF
  • 8. OUTCOME AFTER NEONATAL SEIZURES
  • RENÉE A SHELLHAAS AND COURTNEY J WUSTHOFF
  • 9. “BENIGN” CHILDHOOD EPILEPSY SYNDROMES: WHY DO SOME PRESENT WITH LEARNING PROBLEMS?
  • STÉPHANE AUVIN
  • 10. “BENIGN” INFANTILE EPILEPSIES: IMPACT ON LATER COGNITION AND BEHAVIOUR
  • FEDERICO VIGEVANO AND ROMINA MOAVERO
  • 11. INFANTILE SPASMS: EARLY TREATMENT MAY IMPROVE NEURODEVELOPMENTAL OUTCOMES
  • ANDREW LUX
  • 12. DRAVET SYNDROME: MORE THAN SEIZURES
  • EMMA LOSITO AND RIMA NABBOUT
  • 13. THE EPILEPTIC SYNDROMES WITH CONTINUOUS SPIKES AND WAVES DURING SLOW-WAVE SLEEP
  • PATRICK VAN BOGAERT AND XAVIER DE TIÉGE
  • 14. GLOBAL PROGNOSIS AND NEUROPSYCHOLOGICAL OUTCOME OF LENNOX–GASTAUT SYNDROME
  • ALEXIS ARZIMANOGLOU, ELENI PANAGIOTAKAKI AND ALIA RAMIREZ CAMACHO
  • 15. COGNITIVE AND BEHAVIOURAL OUTCOMES AFTER EPILEPSY SURGERY IN CHILDREN
  • MONIQUE MJ VAN SCHOONEVELD, KEES PJ BRAUN AND J HELEN CROSS