Cognition and Behaviour in Childhood Epilepsy, Lagae, Chapter 7 cover

Cognition and Behaviour in Childhood Epilepsy – Chapter 7: Chronic Cognitive Effects of Antiepileptic Drugs in Childhood Epilepsy (ebook)

Product Type: PDF (Sub-Section of Book)

Series: Clinics in Developmental Medicine

Edition: 1st

Publication date: May 2017

Page count: 13

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Chapter 7 – Chronic Cognitive Effects of Antiepileptic Drugs in Childhood Epilepsy

The cognitive side effects of the antiepileptic drugs (AEDs) have emerged as an important aspect in medical decision making in childhood epilepsy. Children with epilepsy have a higher risk of learning disabilities and academic weakness because of the epilepsy and the seizures. In such a situation, even a modest adverse drug effect may have consequences because it can amplify the already existing weaknesses and ultimately may cause developmental arrest. Children are potentially more susceptible to the adverse effects of AEDs than adults because of the potential effect of AEDs on brain maturation and hence on neurodevelopment. Early identification of AED-induced cognitive impairment in children with epilepsy is, therefore, crucial because those deficits impact on future educational possibilities and eventually the occupational and social outcomes.

About the book

For many parents, cognitive and behavioral comorbidities, such as ADHD, autism and intellectual disability, are the real burden of childhood epilepsy. This title offers concrete guidance and treatment strategies for childhood epilepsy in general, and for the comorbidities associated with each epilepsy syndrome and their pathophysiology. The book is written by experts in the field with an important clinical experience, while chapters by clinical neuropsychologists provide a strong theoretical background.

Readership: Epileptologists, Paediatric Neurologists, Paediatricians and Neuropsychologists.

Albert P Aldenkamp, Willem Lavrijssen and Dominique Ijff (Authors) Lieven Lagae (Editor)

Lieven Lagae is Professor of Paediatric Neurology at the University of Leuven, Belgium (KUL), Head of the Paediatric Neurology Department of the KUL University Hospitals, and Director of the Childhood Epilepsy Program at the KUL University Hospitals. He is the current President of the European Pediatric Neurology Society and serves as an elected Board Member of the International Child Neurology Association (ICNA). From 2004 to 2015 he was the Editor-in-Chief of the European Journal of Paediatric Neurology. His research interests include translational research in zebrafish models of epilepsy, new antiepileptic drugs for childhood epilepsy, brain stimulation and preventive treatment of epilepsy in tuberous sclerosis.

  • Full book contents
  • AUTHORS’ APPOINTMENTS
  • PREFACE
  • 1. COGNITIVE DIFFICULTIES IN CHILDREN WITH EPILEPSY: SOURCES AND IMPLICATIONS
  • ANNE T BERG
  • 2. INTRODUCTORY REMARKS ON NEUROPSYCHOLOGICAL TESTING IN CHILDHOOD EPILEPSY
  • AGATHE LAURENT, FAUSTINE ILSKI-LECOANET AND ALEXIS ARZIMANOGLOU
  • 3. BEHAVIOURAL PROBLEMS IN CHILDHOOD EPILEPSY
  • MELISSA FILIPPINI AND GIUSEPPE GOBBI
  • 4. THE INTERACTION BETWEEN CHILDHOOD-ONSET EPILEPSY AND COGNITON: LONG-TERM FOLLOW UP
  • PETER CAMFIELD AND CAROL CAMFIELD
  • 5. USE OF FUNTIONAL IMAGING TO STUDY COGNITIVE FUNCTIONS
  • MADISON M BERL AND LEIGH N SEPETA
  • 6. DISENTANGLING THE ROLE OF SEIZURES AND EEG ABNORMALITIES IN THE PATHOPHYSIOLOGY OF COGNITIVE DYSFUNCTION
  • JONATHAN K KLEEN AND GREGORY L HOLMES
  • 7. CHRONIC COGNITIVE EFFECTS OF ANTIEPILEPTIC DRUGS IN CHILDHOOD EPILEPSY
  • ALBERT P ALDENKAMP, WILLEM LAVRIJSSEN AND DOMINIQUE IJFF
  • 8. OUTCOME AFTER NEONATAL SEIZURES
  • RENÉE A SHELLHAAS AND COURTNEY J WUSTHOFF
  • 9. “BENIGN” CHILDHOOD EPILEPSY SYNDROMES: WHY DO SOME PRESENT WITH LEARNING PROBLEMS?
  • STÉPHANE AUVIN
  • 10. “BENIGN” INFANTILE EPILEPSIES: IMPACT ON LATER COGNITION AND BEHAVIOUR
  • FEDERICO VIGEVANO AND ROMINA MOAVERO
  • 11. INFANTILE SPASMS: EARLY TREATMENT MAY IMPROVE NEURODEVELOPMENTAL OUTCOMES
  • ANDREW LUX
  • 12. DRAVET SYNDROME: MORE THAN SEIZURES
  • EMMA LOSITO AND RIMA NABBOUT
  • 13. THE EPILEPTIC SYNDROMES WITH CONTINUOUS SPIKES AND WAVES DURING SLOW-WAVE SLEEP
  • PATRICK VAN BOGAERT AND XAVIER DE TIÉGE
  • 14. GLOBAL PROGNOSIS AND NEUROPSYCHOLOGICAL OUTCOME OF LENNOX–GASTAUT SYNDROME
  • ALEXIS ARZIMANOGLOU, ELENI PANAGIOTAKAKI AND ALIA RAMIREZ CAMACHO
  • 15. COGNITIVE AND BEHAVIOURAL OUTCOMES AFTER EPILEPSY SURGERY IN CHILDREN
  • MONIQUE MJ VAN SCHOONEVELD, KEES PJ BRAUN AND J HELEN CROSS