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Comorbidities in Developmental Disorders, Bax, Chapter 3 cover

Comorbidities in Developmental Disorders (Chapter 3) – Gilles De La Tourette Syndrome and its Common Comorbidities

Product Type: PDF (Sub-Section of Book)

Series: Clinics in Developmental Medicine

Edition: 1st

Publication date: November 2011

Page count: 20

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Chapter 3 of the book – Gilles De La Tourette Syndrome and its Common Comorbidities

For well over a century after its first description by George Gilles de la Tourette, the syndrome that bears his name was considered a rare and exotic disease. This view has changed considerably. Epidemiological evidence suggests that Gilles de la Tourette syndrome (GTS) may be far more common than previously estimated, and it is now widely accepted that there is a significant genetic contribution to this neuropsychiatric disorder. However, despite the considerable advances in our understanding of GTS, the genetic basis of GTS remains elusive, the pathophysiology is incompletely understood and any interaction between genetic and potential environmental factors is speculative. From a clinical point of view, treating patients with GTS remains challenging because of the complexities of the clinical phenotype. In this chapter we will try to dissect, as much as is possible, GTS and its most frequent comorbidities, in particular attention-deficit–hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). This may help to improve the understanding of the trials and tribulations of patients with GTS; it also forms the basis of a systematic approach to assessment and treatment.

About the complete book

In the last decade the term ‚’comorbidity‚’ has gained popularity in the field of paediatric neurodisability, with the increasing recognition that many conditions are rarely present in isolation. Within this field, the term is often used to refer to the co-occurrence of conditions more frequently than would be expected by chance, which can include instances where one condition causes the other, where they share a common cause (for example, genetic), or where they are in fact manifestations of a single condition. Whether it is valid to use the term ‚’comorbidity‚’ in all these situations, and how precisely it should be used, is something that the contributors to this book grapple with in their own fields of interest. The contributors, all world experts in their fields, also discuss what we can learn from the presence of comorbidities, however defined, about the aetiology and treatment of neurodevelopmental disabilities. In particular, they demonstrate how our increasing understanding of the mechanisms underlying the common association of many ‘comorbidities‚’ is helping us to understand the natural history of these conditions and improve our management of them.

Readership
Paediatricians, paediatric neurologists, child psychiatrists, neurodevelopmentalists, and physical, occupational and speech therapists working with children with developmental disabilities.

Clinics in Developmental Medicine No. 187

Michael Orth and Mary May Robertson (Authors) Martin Bax (Editor)

Martin Bax was one of the pioneers of community paediatrics and brought a scholarly approach to the subject. He has inspired many paediatricians and has developed an active and productive research group. Dr Bax was for many years senior editor of Developmental Medicine and Child Neurology and was chairperson of the European Academy of Childhood Disability and President of the Society for the Study of Behavioural Phenotypes (SSBP).

Christopher Gillberg (Editor)

Christopher Gillberg is Professor of Child and Adolescent Psychiatry at the University of Gothenburg, and Chief Physician at the Child Neuropsychiatry Clinic at Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg. He is also Professor of Child and Adolescent Psychiatry at University College London (Institute of Child Health), University of Glasgow and at the University of Strathclyde, Glasgow. He is the founding editor of European Child and Adolescent Psychiatry and is or has been on the editorial boards of several journals. He has written or co-authored more than 450 peer-reviewed papers.

  • FULL BOOK CONTENTS
  • AUTHORS' APPOINTMENTS vii
  • FOREWORD ix
  • Christopher Verity
  • INTRODUCTION 1
  • Martin CO Bax and Christopher Gillberg
  • 1 INTELLECTUAL DISABILITIES AND THEIR COMORBIDITIES 7
  • Jeremy Turk
  • 2 HETEROGENEITY IN CEREBRAL PALSY: VARIATIONS
  • IN NEUROLOGY, COMORBIDITY AND ASSOCIATED
  • CONDITIONS 20
  • J Keith Brown and Paul Eunson
  • 3 GILLES DE LA TOURETTE SYNDROME AND ITS COMMON
  • COMORBIDITIES 40
  • Michael Orth and Mary May Robertson
  • 4 COMORBIDITY IN NEURODEVELOPMENTAL DISORDERS:
  • THE CASE OF ATTENTION-DEFICIT--HYPERACTIVITY DISORDER 60
  • Eric Taylor
  • 5 EARLY LANGUAGE DISORDER AS A FREQUENT
  • COMORBIDITY IN MANY DEVELOPMENTAL DISORDERS
  • IN YOUNG CHILDREN 75
  • Isabelle Rapin
  • 6 AUTISM AND EPILEPSY: COMORBIDITY, COEXISTENCE OR
  • COINCIDENCE? 89
  • Christopher Gillberg and Brian Neville
  • 7 GENETIC CORRELATES OF PSYCHIATRIC COMORBIDITY:
  • FRAGILE X SYNDROME 101
  • Sufen Chiu, David Hessl, Josh Day and Randi Hagerman
  • 8 CHANNELOPATHIES 116
  • Sameer M Zuberi
  • 9 INCREASED LONGEVITY AND THE COMORBIDITIES
  • ASSOCIATED WITH INTELLECTUAL AND DEVELOPMENTAL
  • DISABILITY 125
  • Alan H Bittles and Emma J Glasson
  • 10 COMORBIDITY: CLASSIFICATION ARTEFACT AND
  • CLINICAL REALITY 142
  • Rutger Jan van der Gaag
  • INDEX 149

'Every chapter was enjoyable and easy to read and full of the understanding of nuances that only an expert can bring to a presentation. All of them have what physicians my age call "pearls", little known facts that are memorable because they are surprising or useful (or both). The chapter on the heterogeneity of cerebral palsy by Brown and Eunson has the largest number of these. I have never read clearer discussions of comorbid disorders in Tourette syndrome (Orth and Robertson), in ADHD (Taylor), in early language disorder (Rabin), and of autism and epilepsy (Gillberg and Neville). All chapters are very good but these five are excellent.' Gordon Worley, DMCN, 2011

'This compact book will make a useful contribution for both child psychiatrists and community paediatricians working with children with developmental disorders.' Felicity Hepper, Child and Adolescent Mental Health, 2011

'When you face a child who manifests seemingly multiple disabilities, which is the rule rather than the exception, this book will be an invaluable tool for your knowledge, reflection, and action.' Motohide Miyahara, International Journal of Disability, Development and Education, 2011