Dattani, Neuroendocrine Disorders in Children, Chapter 1 cover

Neuroendocrine Disorders in Children – Chapter 1: Neuroendocrine Regulation of Growth Hormone Secretion (free ebook)

This chapter is part of Neuroendocrine Disorders in Children

Product Type: PDF (Sub-Section of Book)

Series: Clinics in Developmental Medicine

Edition: 1st

Publication date: September 2016

Page count: 12

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Chapter 1 – Neuroendocrine Regulation of Growth Hormone Secretion by Peter C Hindmarsh and Iain CAF Robinson from Neuroendocrine Disorders in Children 

The entire process of human growth represents a continuum to which birth is largely incidental. Postnatal growth can be considered to consist of at least three distinct phases: infancy, childhood and puberty. The infancy component is largely a continuation of the longitudinal growth process observed in utero. This displays a peak length velocity around 27 to 28 weeks of gestation, with a decline in growth rate during the last trimester of pregnancy. This declining growth rate continues during the first 3 years of life, reaching a plateau at or around the fourth year of life and continues at this rate until the commencement of the pubertal growth spurt.

About the Complete Book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Readership

Paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.

Full Book Review

Read the full book review by Ieuan Hughes published in Developmental Medicine and Child Neurology.

Video from the Editor

Clinics in Developmental Medicine Series

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Peter C Hindmarsh and Iain CAF Robinson (Authors) Mehul Dattani (Editor)

Prof Mehul Dattani

Mehul Dattani leads paediatric and adolescent endocrinology at Great Ormond Street Hospital for Children, London. His research interests are in the area of growth, pituitary development and disorders of puberty. Professor Dattani has received a number of national and international awards for his research work. He is currently Chair of the Programme Organizing Committee of the European Society for Paediatric Endocrinology.

Peter Hindmarsh (Editor)

Prof Peter Hindmarsh

Peter Hindmarsh is Professor of Paediatric Endocrinology at University College London and Divisional Clinical Director at the University College London Hospitals. His research interests include mathematical modelling of feedback systems including growth hormone, cortisol and insulin. He served as Chair of the working party on diabetes whose work led to major improvements in paediatric diabetes care in the UK.

Lucinda Carr (Editor)

Lucinda Carr

Lucinda Carr is Consultant Paediatric Neurologist at Great Ormond Street Hospital for Children, London, working across the departments of neurology and neurodisability. She served as the clinical lead in neurology at the hospital from 2008 to 2013. Dr Carr's main research interest is in movement disorders and cerebral palsy and she was a member of the team that developed the NICE guidelines on the management of spasticity in children.

Iain C A F Robinson (Editor)

Iain Robinson was head of the Division of Molecular Neuroendocrinology at the Medical Research Council National Institute for Medical Research until retirement in 2009. A major focus of interest was the study of hypothalmo-pituitary defects that cause growth retardation in children. His is group pioneered microsampling techniques in experimental animals and neonates, as well as developing novel transgenic and imaging techniques.

  • Full book contents
  • FOREWORD xiv
  • PREFACE xvi
  • SECTION 1: THE GH-IGF1 AXIS AND THE BRAIN
  • 1. NEUROENDOCRINE REGULATION OF GROWTH HORMONE
  • SECRETION 1
  • Peter C Hindmarsh and Iain CAF Robinson
  • 2. DISORDERS OF THE HYPOTHALAMO-PITUITARY-SOMATOTROPH
  • AXIS LEADING TO GROWTH FAILURE 13
  • Kyriaki S Alatzoglou and Mehul T Dattani
  • 3. THE EFFECT OF GROWTH HORMONE ON THE BRAIN 30
  • Fred Nyberg, Alfhild Grönbladh, Erika Brolin, Anna Jonsson,
  • Jenny Johansson and Mathias Hallberg
  • 4. IMPACT OF DISORDERS OF THE GROWTH HORMONE–IGF-1
  • AXIS ON NEUROLOGICAL FUNCTION 42
  • Emma A Webb and Mehul T Dattani
  • 5. NEUROENDOCRINE DISORDERS OF SALT AND WATER BALANCE 55
  • Joseph A Majzoub
  • SECTION 2: THE THYROID AXIS AND THE BRAIN
  • 6. THE HYPOTHALAMIC-PITUITARY-THYROID AXIS: ANATOMY
  • AND PHYSIOLOGY 74
  • Mary-Jane Brassill, Apostolos I Gogakos, John G Logan,
  • Julian A Waung and Graham R Williams
  • 7. DISORDERS OF THE HYPOTHALAMO-PITUITARY-THYROID AXIS 87
  • Tim Cheetham and Ramesh Srinivasan
  • 8. IMPACT OF THYROID DISORDERS ON NEUROLOGICAL FUNCTION 104
  • Joanne F Rovet
  • SECTION 3: REGULATION OF APPETITE AND WEIGHT
  • 9. THE ROLE OF THE HYPOTHALAMUS IN NORMAL WEIGHT
  • REGULATION 117
  • Simon M Luckman
  • 10. GENETIC CHILDHOOD OBESITY SYNDROMES 131
  • I Sadaf Farooqi
  • 11. TREATMENT OF OBESITY 142
  • Terry Segal and Bhavni Shah
  • SECTION 4: EFFECTS OF THE TREATMENT OF CANCER ON THE NEUROENDOCRINE SYSTEM
  • 12. LATE EFFECTS OF CANCER AND ITS TREATMENTS ON THE NEUROENDOCRINE SYSTEM 167
  • Wassim Chemaitilly and Charles A Sklar
  • 13. CRANIOPHARYNGIOMA 182
  • Hoong-Wei Gan, Juan Pedro Martinez-Barbera,
  • Helen A Spoudeas and Mehul T Dattani
  • SECTION 5: ADRENAL DISORDERS AND THE BRAIN
  • 14. THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS AND
  • ITS REGULATION 206
  • Elizabeth Baranowski, Tulay Guran and Nils Krone
  • 15. THE EFFECT OF STRESS ON THE HYPOTHALAMIC-PITUITARY-
  • ADRENAL AXIS: AN UPDATE 218
  • Evangelia Charmandari and George P Chrousos
  • 16. ADRENOLEUKODYSTROPHY: NEUROLOGICAL ASPECTS 234
  • Patrick Aubourg
  • 17. CUSHING DISEASE: DIAGNOSIS AND MANAGEMENT 242
  • Helen L Storr and Martin O Savage
  • SECTION 6: NEUROENDOCRINOLOGY AND THE REPRODUCTIVE AXIS
  • 18. THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS 255
  • Pierre-Marc G Bouloux
  • Neuroendocrine Disorders

'I found the remarks on genetic childhood obesity syndromes, Kallmann syndrome, and on effects of stress on the hypothalamic–pituitary–adrenal axis particularly informative. This volume can be recommended as a valuable source of up-to-date information about physiology, pathophysiology, molecular biology, and novel genetic aspects.' Eugen Boltshauser, Neuropediatrics, 2016

'The Clinics books are intended to be an in-depth, up-to-date study of a particular topic. This book fills the bill. Each chapter provides a review of a specific topic then presents the most current research with a view to clinical application. The forward by Mitchell E. Geffner says it best “a one-stop shop for brain-hypothalamic-pituitary hormonal physiology and pathophysiology”. In each section the interplay between genetics and neuroendrocrine systems are an essential component. The effects of endrocrine disorders on the brain are also discussed in detail... I learned what we should be looking for in children we suspect may have neuroendocrine disorders but I also gained an understanding of how this system drives us and our patients to homeostasis, or not and the far reaching consequences of errors in the system.' American Academy for Cerebral Palsy & Developmental Medicine Newsletter, 2016

'This is a superb book on neuroendocrinology which, by its choice of topics and detailed content, is effectively a book on the entirety of endocrinology. The book will appeal to a wide audience, young and old, and across the spectrum of health professionals caring for children with endocrine problems.' Ieuan Hughes, Developmental Medicine & Child Neurology, 2017