Neuroendocrine Disorders in Children – Chapter 7: Disorders of the Hypothalamo-Pituitary-Thyroid Axis (ebook)
This chapter is part of Neuroendocrine Disorders in Children
Product Type: PDF (Sub-Section of Book)
Series: Clinics in Developmental Medicine
Edition: 1st
Publication date: September 2016
Page count: 17
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Chapter 7 – Disorders of the Hypothalamo-Pituitary-Thyroid Axis
Thyroid hormones play a critical role in brain development. One of the major successes of paediatric endocrinology has been the introduction of the newborn blood spot screening programme for congenital hypothyroidism (CHT). This has led to the virtual elimination of CHT with its attendant mental impairment in participating nations. The recognition that endemic cretinism can be easily alleviated by iodine supplementation has also changed the lives of many for the better. This chapter addresses various causes of thyroid hormone deficiency or lack of action, all of which have the potential to impair neurological development.
About the book
Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children. These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.
Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.
Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.
Read the full book review by Ieuan Hughes published in DMCN.
- Full book contents
- FOREWORD xiv
- PREFACE xvi
- SECTION 1: THE GH-IGF1 AXIS AND THE BRAIN
- 1. NEUROENDOCRINE REGULATION OF GROWTH HORMONE
- SECRETION 1
- Peter C Hindmarsh and Iain CAF Robinson
- 2. DISORDERS OF THE HYPOTHALAMO-PITUITARY-SOMATOTROPH
- AXIS LEADING TO GROWTH FAILURE 13
- Kyriaki S Alatzoglou and Mehul T Dattani
- 3. THE EFFECT OF GROWTH HORMONE ON THE BRAIN 30
- Fred Nyberg, Alfhild Grönbladh, Erika Brolin, Anna Jonsson,
- Jenny Johansson and Mathias Hallberg
- 4. IMPACT OF DISORDERS OF THE GROWTH HORMONE–IGF-1
- AXIS ON NEUROLOGICAL FUNCTION 42
- Emma A Webb and Mehul T Dattani
- 5. NEUROENDOCRINE DISORDERS OF SALT AND WATER BALANCE 55
- Joseph A Majzoub
- SECTION 2: THE THYROID AXIS AND THE BRAIN
- 6. THE HYPOTHALAMIC-PITUITARY-THYROID AXIS: ANATOMY
- AND PHYSIOLOGY 74
- Mary-Jane Brassill, Apostolos I Gogakos, John G Logan,
- Julian A Waung and Graham R Williams
- 7. DISORDERS OF THE HYPOTHALAMO-PITUITARY-THYROID AXIS 87
- Tim Cheetham and Ramesh Srinivasan
- 8. IMPACT OF THYROID DISORDERS ON NEUROLOGICAL FUNCTION 104
- Joanne F Rovet
- SECTION 3: REGULATION OF APPETITE AND WEIGHT
- 9. THE ROLE OF THE HYPOTHALAMUS IN NORMAL WEIGHT
- REGULATION 117
- Simon M Luckman
- 10. GENETIC CHILDHOOD OBESITY SYNDROMES 131
- I Sadaf Farooqi
- 11. TREATMENT OF OBESITY 142
- Terry Segal and Bhavni Shah
- SECTION 4: EFFECTS OF THE TREATMENT OF CANCER ON THE NEUROENDOCRINE SYSTEM
- 12. LATE EFFECTS OF CANCER AND ITS TREATMENTS ON THE NEUROENDOCRINE SYSTEM 167
- Wassim Chemaitilly and Charles A Sklar
- 13. CRANIOPHARYNGIOMA 182
- Hoong-Wei Gan, Juan Pedro Martinez-Barbera,
- Helen A Spoudeas and Mehul T Dattani
- SECTION 5: ADRENAL DISORDERS AND THE BRAIN
- 14. THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS AND
- ITS REGULATION 206
- Elizabeth Baranowski, Tulay Guran and Nils Krone
- 15. THE EFFECT OF STRESS ON THE HYPOTHALAMIC-PITUITARY-
- ADRENAL AXIS: AN UPDATE 218
- Evangelia Charmandari and George P Chrousos
- 16. ADRENOLEUKODYSTROPHY: NEUROLOGICAL ASPECTS 234
- Patrick Aubourg
- 17. CUSHING DISEASE: DIAGNOSIS AND MANAGEMENT 242
- Helen L Storr and Martin O Savage
- SECTION 6: NEUROENDOCRINOLOGY AND THE REPRODUCTIVE AXIS
- 18. THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS 255
- Pierre-Marc G Bouloux
- Neuroendocrine Disorders
'I found the remarks on genetic childhood obesity syndromes, Kallmann syndrome, and on effects of stress on the hypothalamic–pituitary–adrenal axis particularly informative. This volume can be recommended as a valuable source of up-to-date information about physiology, pathophysiology, molecular biology, and novel genetic aspects.' Eugen Boltshauser, Neuropediatrics, November 2016
'The Clinics books are intended to be an in-depth, up-to-date study of a particular topic. This book fills the bill. Each chapter provides a review of a specific topic then presents the most current research with a view to clinical application. The forward by Mitchell E. Geffner says it best “a one-stop shop for brain-hypothalamic-pituitary hormonal physiology and pathophysiology”. In each section the interplay between genetics and neuroendrocrine systems are an essential component. The effects of endrocrine disorders on the brain are also discussed in detail... I learned what we should be looking for in children we suspect may have neuroendocrine disorders but I also gained an understanding of how this system drives us and our patients to homeostasis, or not and the far reaching consequences of errors in the system.' AACPDM eNewsletter, Winter 2016
- Neuroendocrine Disorders in Children - Chapter 1: Neuroendocrine Regulation of Growth Hormone Secretion (free ebook)
- Neuroendocrine Disorders in Children - Chapter 22: Diabetes and the Developing Brain (ebook)
- Neuroendocrine Disorders in Children - Chapter 21: Psychological and Behavioural Consequences of Gonadal Hormone Abnormality During Early Development (ebook)
- Neuroendocrine Disorders in Children - Chapter 20: Precocious Puberty (ebook)
- Neuroendocrine Disorders in Children - Chapter 19: The Inherited Basis of Hypogonadotropic Hypogonadism (ebook)
- Neuroendocrine Disorders in Children - Chapter 18: The Hypothalamic-Pituitary-Gonadal Axis (ebook)
- Neuroendocrine Disorders in Children - Chapter 17: Cushing Disease: Diagnosis and Management (ebook)
- Neuroendocrine Disorders in Children - Chapter 16: Adrenoleukodystrophy: Neurological Aspects (ebook)
- Neuroendocrine Disorders in Children - Chapter 15: The Effect of Stress on the Hypothalamic-Pituitary-Adrenal Axis (ebook)
- Neuroendocrine Disorders in Children - Chapter 14: The Hypothalamo-Pituitary-Adrenal Axis and its Regulation (ebook)
- Neuroendocrine Disorders in Children - Chapter 23: Central Actions of Insulin (ebook)
- Neuroendocrine Disorders in Children - Chapter 13: Craniopharyngioma (ebook)
- Neuroendocrine Disorders in Children - Chapter 12: Late Effects of Cancer and its Treatments on the Neuroendocrine System (ebook)
- Neuroendocrine Disorders in Children - Chapter 11: Treatment of Obesity (ebook)
- Neuroendocrine Disorders in Children - Chapter 10: Genetic Childhood Obesity Syndromes (ebook)
- Neuroendocrine Disorders in Children - Chapter 9: The Role of the Hypothalamus in Normal Weight Regulation (ebook)
- Neuroendocrine Disorders in Children - Chapter 8: Impact of Thyroid Disorders on Neurological Function (ebook)
- Neuroendocrine Disorders in Children - Chapter 7: Disorders of the Hypothalamo-Pituitary-Thyroid Axis (ebook)
- Neuroendocrine Disorders in Children - Chapter 6: The Hypothalamic-Pituitary-Thyroid Axis (ebook)
- Neuroendocrine Disorders in Children - Chapter 5: Neuroendocrine Disorders of Salt and Water Balance (ebook)
- Neuroendocrine Disorders in Children - Chapter 4: Impact of Disorders of the Growth Hormone–IGF-1 Axis on Neurological Function (ebook)
- Neuroendocrine Disorders in Children - Chapter 3: The Effect of Growth Hormone on the Brain (ebook)
- Neuroendocrine Disorders in Children - Chapter 2: Disorders of the Hypothalamo-Pituitary-Somatotroph Axis Leading to Growth Failure (ebook)