Central Nervous System Tumours of Childhood

Ranging from epidemiology and neuroimaging through the general principles of surgery and radiotherapy/chemotherapy to issues of palliative care and quality of life, this concise, broad-ranging and practical text covers all clinical aspects of central nervous system tumours in children.

It provides an overview of current important issues in diagnosis and management, and focuses on important areas of research, with an emphasis on the areas likely to impact on clinical practice.

It is essential reading for paediatric oncologists, medical and clinical oncologists, neurosurgeons, and paediatricians involved in the care of children with brain tumours, trainees in these and related specialties, specialist nurses and paramedical staff.

Clinics in Developmental Medicine No. 166

Cerebellar Disorders in Children

This comprehensive clinically orientated text by an international group of experts is the first definitive reference book on disorders of the cerebellum in children. An invaluable resource for all those caring for children affected by cerebellar disorders, it presents a wealth of practical clinical experience backed up by a strong scientific basis for the information and guidance given.

The first part sets out the theoretical underpinnings of cerebellar disorders. This is followed by sections on clinical conditions grouped according to common characteristics such as aetiology and symptomatology. The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis, and management and treatment.

The book includes chapters on cerebellar development, prenatal cerebellar imaging, imaging of the posterior fossa, with coverage of a broad range of malformations, genetic and metabolic disorders involving the cerebellum, prenatal cerebellar disruptions (as related to prematurity), vascular disorders, tumors and paraneoplastic syndromes, as well as acute ataxia and trauma to the posterior fossa. Numerous checklists are provided to assist in the differential diagnosis of clinical signs and neuroimaging findings.

Readership 
Paediatric neurologists, paediatricians, neurologists, developmental paediatricians, neuroimaging specialists, geneticists, neonatologists

Clinics in Developmental Medicine No. 191-192

Childhood Headache, 2nd Edition

Headache as a common problem which has a significant impact on children’s quality of life. This book provides practising clinicians with a comprehensive source of advice and knowledge on the diagnosis and management of childhood headache disorders. It addresses the needs of clinicians looking after children with headache, whether it was in a primary care setting, a hospital general paediatric clinic or in a specialist paediatric neurology service.

Assessment of the child with chronic headache takes a central position, with two chapters to help early diagnosis of the child with a serious neurological disorder. The scientific basis of headache and migraine is clearly presented and simplified in the chapter of pathophysiology. Many clinical cases are presented to illustrate the complexity, the importance or the rarity of certain headache disorders and bring to life the relevant models of assessment and management. The book also highlights the results of recent research and provides critical analysis of commonly accepted classification of headache disorders and also provides pointers of future research needs.

  • Written by world experts who are leaders in the field of headache in children, giving a global perspective
  • Authors brings their clinical experience to life with real case vignettes
  • The only book of its kind to maintain an excellent balance of clinical focus and research
  • Explores the current evidence base into the causes and treatments of childhood headache
  • The clinical recommendations are applicable anywhere in the world
  • The book is easy to read and fully referenced

Readership

A comprehensive source of knowledge and guidance to practising clinicians looking after children with headache which includes many clinical examples to illustrate the difficulties in diagnosis or options for treatment. It is also a resource for researchers who are looking for a full analysis of the published studies.

Clinics in Developmental Medicine Series

Aicardi’s Diseases of the Nervous System in Childhood, 4th Edition

The Premier Reference Book on Clinical Child Neurology

Congenital or early-onset disorders of the nervous system have a profound and lifelong impact on the lives of children and their families. Aicardi’s Diseases of the Nervous System in Childhood, 4th Edition provides up-to-date information on the full range of these neurological disorders, from fetal and neonatal neurology to adolescence.

Movement disorders, epilepsies and seizure disorders, metabolic diseases, auditory and visual disorders, and genetic anomalies are among the many topics covered in this text. Extensive reference lists at the end of each chapter guide the clinician to further relevant reading.

This fourth edition retains the patient-focussed, clinical approach of its predecessors. The international team of editors and contributors has honoured the request of the late Jean Aicardi, that his book remain ‘resolutely clinical’, which distinguishes Aicardi’s Diseases of the Nervous System in Childhood from other texts in the field. For further information about the history of this title and previous editions, please see Further Materials.

This edition:

  • Is completely revised and updated
  • Includes latest developments in genetic advances
  • Contains new chapters on basal ganglia diseases and psychogenic disorders
  • Has an easy-to-use one volume format with full-colour illustrations

Aicardi’s Diseases of the Nervous System in Childhood, 4th Edition remains the classic, user-friendly resource for busy clinicians in paediatric neurology, child neurology, general paediatrics, neurodisability, and all related medical disciplines.

Clinics in Developmental Medicine

Quadruplets and Higher Multiple Births

Improved neonatal care and nutrition have meant that many more babies from quadruplet and higher-order conceptions survive than in the past. In this book, the author brings together what is known from historical records and reports in the medical, psychological, and popular press on the lives of these children and the psychodevelopmental consequences of their multiple status. She points to the contribution that research studies on higher multiple sets could make to our understanding of genetic-environmental interactions and gives valuable methodological advice for those wishing to initiate such a study. Changes in social practices and medical knowledge are highlighted, various aspects of pregnancy and birth are discussed, and the practical and emotional problems faced by families of multiple sets are sensitively described. Appended to the book is an illustrated catalogue of quadruplet case reports gleaned from the literature, including birth details and postnatal histories.

Clinics in Developmental Medicine No. 107

Cerebral Palsy: Science and Clinical Practice

Cerebral Palsy book cover

This landmark title considers all aspects of cerebral palsy from the causes to clinical problems and their implications for individuals.

An international team of experts provides clinicians and researchers with key information on the mechanisms underlying impairments in movement, development, cognition, communication, vision, feeding, behaviour, sexuality, and musculoskeletal deformities.

They present a wide range of person-centred assessment approaches, including clinical evaluation, measurement scales, neuroimaging and gait analysis. The principles of multi-disciplinary management are presented, in terms of therapist intervention, medication and surgery. The perspective of the book spans the lifelong course of cerebral palsy, taking into account worldwide differences in socio-economic and cultural factors. Many chapters are illustrated with clinical vignettes enabling direct translation into practice. Full integrated colour, with extensive cross-referencing make this a highly attractive and useful reference.

Paediatric neurologists, developmental paediatricians, rehabilitation doctors, orthopaedic surgeons, child psychiatrists, physiotherapists speech and language therapists psychologists, occupational therapists and other health and educational professionals.

Clinics in Developmental Medicine

Neonatal Behavioral Assessment Scale, 4th Edition

  • Fourth edition of the most comprehensive examination of newborn behavior available
  • Well established and used globally as a research instrument and in clinical practice
  • Case studies from a range of disciplines and settings enrich this edition
  • New administration guidelines and refined scoring criteria for researchers and clinicians

The Neonatal Behavioral Assessment Scale (NBAS) is the most comprehensive examination of newborn behaviour available today and has been used in clinical and research settings around the world for more than 35 years.

The scale assesses the newborn’s behavioral repertoire with 28 behavioral items and also includes an assessment of the infant’s neurological status on 20 items.

The NBAS items cover the following domains of neonatal functioning: autonomic regulation; motor organization; state organization and regulation and attention/social interaction.

The first part of this new edition book describes in detail the procedures involved in administering and scoring the NBAS. This is followed by chapters setting the assessment in the context of psychological influences around birth, the relationship between the examiner, infant and parents, and what we know about newborn motor behaviour. After a chapter on the use of the NBAS in research settings, the final part comprises descriptions by professionals around the world of its use in clinical practice.

Since the time it was first published, the NBAS has been used in hundreds of studies to examine the effects of a wide range of pre- and perinatal variables. This new edition therefore contains an updated review of research using the NBAS. Because the NBAS is being used increasingly as a way of promoting a positive relationship between parent and child, the new edition also includes new guidelines for clinicians. New guidelines and numerous refinements in the administration and scoring have now been added, and a section describing advances in our understanding of motor behaviour has been added. Finally, new chapters present the uses of the NBAS in a range of contexts around the world, highlighting the wide range of research and clinical applications of the NBAS.

Readership
Paediatricians, neonatologists, all those involved in the examination of the newborn infant including, for example, nurses, psychologists, infancy specialists, lactation consultants, home visitors, occupational therapists, physical therapists, early intervention specialists, social workers and other allied health professionals (all of whom attend NBAS training courses).

Clinics in Developmental Medicine No. 190

Feeding the Disabled Child

Disabled children often have feeding difficulty. Choking, food spillage and protracted mealtimes can pose enormous problems for their carers and the accompanying nutritional deficit imposes additional burdens on the affected child.

In this book the aetiology of these problems is placed in context by a detailed description of normal feeding development in infants. The often under-recognised nutritional and neurodevelopmental consequences of inadequate nutrient intake together with the respiratory complications and the important problems of constipation and drooling, which may accompany oromotor dysfunction, are detailed. The clinical and nutritional assessment and the application of diagnostic imaging techniques in the evaluation of such children are described. The methods of management of these children’s problems form the core of this volume and they range from oromotor therapy to various techniques for enteral feeding. The ethical issues raised by the vigorous intervention needed to improve the nutritional state of severely disabled children is explored, together with the need to provide ongoing psychological support for their carers.

Clinics in Developmental Medicine No. 140

Developmental Disability and Behaviour

This book reviews clinical models for working with developmental disability and behavioural problems. The first section explores the causes and nature of behaviour problems amongst people with physical, learning, language and sensory disabilities, and some key specific conditions. The second section describes the assessment approaches that clinicians will find most useful in evaluating behaviour. The third section covers treatment approaches emphasising the importance of a broad, eclectic approach. The contributors, all acknowledged experts in their fields of paediatrics, psychology and psychiatry, provide a comprehensive overview of this set of major challenges, emphasising the importance of auditory detection, understanding, measurement and treatment.

Clinics in Developmental Medicine No. 149

Angelman Syndrome

This book provides a comprehensive review of clinical and genetic issues, natural history, possible pathophysiological pathways, specific clinical problems (motor impairment, behaviour, learning difficulties, communication, sleep, epilepsy), clinical neurophysiology, neuropathology, rehabilitation and basic research in the field of Angelman syndrome.

This condition is a neurogenetic disorder characterised by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioural phenotype. It is caused by the lack of expression of the UBE3A gene associated with various abnormalities of chromosome 15q11-13. Angelman syndrome appears to be distributed equally worldwide. Precise diagnosis carries clinical and genetic counselling implications. However, many clinicians still seem unfamiliar with this condition despite the severity and typical aspects of presentation.

Beyond individual situations, Angelman syndrome can serve as a disease model opening broad questioning of genetic and epigenetic influences in neurology, as well as of several concepts such as psychomotor development, cerebral palsy, behavioural phenotypes and epileptic syndromes.

Recent advances in molecular biology and animal models of the syndrome have provided new data which can improve our understanding of Angelman syndrome and open the way to more specific management.

Clinics in Developmental Medicine No. 177