Stroke and Cerebrovascular Disease in Childhood

The field of stroke and cerebrovascular disease in children is one in which there has been much recent research activity, leading to new clinical perspectives.

This book for the first time summarizes the state of the art in this field. A team of eminent clinicians, neurologists and researchers provide an up-to-the-minute account of all aspects of stroke and cerebrovascular disease in children, ranging from a historical perspective to future directions, through epidemiology, the latest neuroimaging techniques, neurodevelopment, comorbidities, diagnosis and treatment. The authors’ practical approach to the clinical problems makes this essential reading for practising clinicians. It will also be of interest to researchers in the field.

International Review of Child Neurology Series No. 11

Tuberous Sclerosis Complex

‘This is clearly the most authoritative and contemporary statement of current knowledge yet published.’ H. Sarnat, Foreword

Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes.

This book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease.


Paediatricians and child neurologists will find this book uniquely useful.

International Review of Child Neurology Series No. 6

Vitamin-Responsive Conditions in Paediatric Neurology

This book, in the International Child Neurology Review series, is the first authoritative synthesis of the role of vitamin treatments in children with neurological disorders.

It covers all the conditions seen in paediatric neurology that are treatable by vitamin supplementation and consists of up-to-date, concise reviews by an international group of experts in their specific fields. They cover: biotinidase deficiency; the role of vitamins in the developing nervous system, mitochondrial disorders and autism; homocysteinuria; conditions responsive to vitamin E or riboflavin; disorders of folic acid and vitamin B12 metabolism; folinic acid responsive seizures, and all aspects of pyridoxine-dependent and pyridoxine-responsive seizures.

It is the first time that clinical and data research in this field has been drawn together in one source, making available previously unpublished material. This is a unique data resource for anyone involved in the care of children with vitamin-responsive neurological disorders.

International Review of Child Neurology Series No. 4

Pediatric Clinical Neurophysiology

Pediatric Clinical Neurophysiology introduces clinical neurophysiology and its applications to the paediatric neurologist. It does not aim at being a textbook of either clinical neurophysiology or paediatric neurology, but to bridge these entities, as a handbook for the clinician. The focus is on the methods applied in the setting of a clinical neurophysiological laboratory. It will stimulate readers’ interest in paediatric clinical neurophysiology in their daily clinical work with children.

International Review of Child Neurology Series No. 8

Peripheral Neuropathy in Childhood, 2nd Edition

Peripheral neuropathies are diseases which affect the neuromuscular apparatus between the muscles or sensory receptors and connections in the spinal cord and the brain. They affect approximately 20-30% of children attending neuromuscular clinics.

Uniquely, this text deals exclusively with such disorders in children and draws together the rapidly expanding but widely scattered knowledge in the field. It is a highly practical text, written by clinical neurologists with long experience in physiology, histopathology and management of neuropathy. This second edition retains the basic structure of its successful predecessor and continues to be liberally illustrated with real case histories. However, extensive revisions and expansion of the text have enabled it to encompass the major developments, including recent advances in molecular biology and therapy of metabolic and inflammatory neuropathies.

International Review of Child Neurology Series No. 2

Movement Disorders in Children

Movement Disorders in Children brings the combined expertise and experience of two world-known authorities to the systematic and practical study of movement disorders in infancy and childhood.

Aimed at the clinicians and professionals who manage children with these disorders, Emilio Fernandez-Alvarez and Jean Aicardi cover not only the well-known diseases, but also the less well-known conditions, such as ‘transient’ and ‘paroxysmal’ movement disorders.

It is the first time all the available information, currently spread throughout journals and individual chapters in other books, has been brought together in one volume and specifically directed towards the care of children with movement disorders.

With its clinical emphasis, full coverage and extensive but selective references, this book is essential reading for child neurologists, pediatricians and physiotherapists.

International Review of Child Neurology Series No. 3

Neonatal Seizures

A better understanding of neural activity and the development of cortical connections and networks is an important requirement for evaluating the cause and treatment of neonatal seizures.

There have been many advances in the management of neonatal seizures such as increased use of EEGs, therapeutic hypothermia for HIE and exome sequencing, to name a few. Neonatal Seizures, Current Management, Future Challenges distils what is known about these advances into one scholarly yet practical text.

Full Book Review

Read the full book review by Janet M Rennie published in Developmental Medicine & Child Neurology.


Neonatologists, paediatricians, neurologists, neurophysiology technologists, and other health professionals who care for neonates with seizures.


Neurodevelopmental Disabilities: Clinical and Scientific Foundations

Neurodevelopmental disabilities are a common problem in child health.

This book takes a comprehensive approach to addressing these often challenging clinical diagnoses. In particular, it focuses on the two most common of childhood neurodevelopmental disabilities: global developmental delay and developmental language impairment.

It seeks to put forward our present conceptualization of these entities as well as their proper evaluation and assessment and diagnosis from a variety of perspectives. It also provides details on our current understanding of the scientific basis of these disorders and their underlying causes. Issues related to medical management, rehabilitation, and eventual outcomes are also addressed in a detailed way.

The book has wide appeal to those in paediatrics, developmental paediatrics, child neurology, and paediatric rehabilitation. Its geographic appeal includes both developed and developing nations as some chapters are devoted to the particular issues faced in underdeveloped countries.

The book’s focus on both clinical and scientific aspects is invaluable in this field. It also provides extensive information in a single source relating to often-overlooked areas such as medical management, rehabilitation, public policy, and ethics.

International Review of Child Neurology Series No. 10

Neurofibromatosis Type 1 in Childhood

A great deal is now known about neurofibromatosis type 1, particularly as a result of the identification of its causative gene by positional cloning.

Effective treatments for its resulting cosmetic disfigurement, impaired cognitive performance and even life-threatening malignancy however sadly remain elusive.

As Dr Korf remarks in his Foreword;

‘this book’s cogent and thorough description of neurofibromatosis in children will take its place alongside other major clinical studies of the disorder. (Dr North) has tackled some of the more challenging issues, such as the basis for learning disabilities and the optimal means for early detection of optic gliomas. Her work provides a guide to the clinician and stands as a provocative challenge to the neurofibromatosis research community to further explore the basis of these problems.’

International Review of Child Neurology Series No. 1

Head Injury in Children and Adolescents

This is a comprehensive framework for the care needed by children and their families following a traumatic brain injury.

From the Preface:

‘Traumatic brain injury in children and adolescents is a significant epidemiological and health problem in all countries of the world.  Severe brain injury forever alters the lives of affected children and their families. What has become clear is that there is also a ‘silent epidemic’ of mild head injury and that many children – for what is now recognized as the result of individual genetic differences and vulnerabilities of injury characteristics – are at risk for significant long-term cognitive and behavioural disabilities of varying severity. The future will hold promise for children who have had traumatic brain injury; neuroprotective strategies, advanced treatment in neurointensive settings and new rehabilitation approaches will all play a role in reducing disability. Preventive measures – with the regulatory and legislative strength of governments – hold the key to reduction in the incidence of traumatic brain injury.’

International Review of Child Neurology Series No. 9