- Well over 200 illustrations, many in colour
- Co-authored by two experts in neuropathology and neuroimaging
- Takes a quantitative approach to brain growth in weight, gyrus formation, myelination, and spectroscopy of the developing brain
- The only book in this field to include chapters in angiogenesis, fetal behaviour, and reactions to chronic illness
This book is about human brain development, focusing on the last half of gestation and the neonatal and infant periods. These periods bring the greatest risk for the acquisition of childhood functional neurologic deficits, including cerebral palsy, developmental delay and intellectual disability.
Section 1 covers typical development, including growth in brain weight, ventricular surfaces, gyral development, myelinated tract development, magnetic resonance spectroscopy, and angiogenesis, all serving as reference points for section 2, which deals with common acquired brain abnormalities, some of which are often underemphasized or overlooked.
The topics in section 2 include retrocerebellar cysts, abnormal events in fetal brain, white-matter abnormalities, lesions of gray and white matter, hemorrhage, ventriculomegaly and hydrocephalus, late expressions of fetal brain disease, and reactions of the developing brain to chronic disease. Between sections 1 and 2 is a chapter on embryonic and fetal physiologic reactions to external stimuli.
Where appropriate, the authors have combined pathologic with neuroimaging examples to help the reader better understand the neuroimages that they encounter.
Much of the information in the book is based on data from the National Collaborative Perinatal Project, still the only large autopsy survey of late fetal brain lesions.
Developmental neurobiologists, neuroscientists, paediatricians, neuropathologists, pediatric neuroradiologists, pediatric neurologists, neonatologists, perinatologists.
Clinics in Developmental Medicine No. 193
1. INTRODUCTION 1
SECTION 1 11
2. BRAIN GROWTH 13
3. FETAL VENTRICULAR SIZE, SURFACES, AND APPENDAGES 28
4. GERMINAL TISSUE (SUBVENTRICULAR ZONE) 48
5. SURFACE CONFIGURATION-GYRAL PATTERN DEVELOPMENT 65
6. MYELINATED TRACTS: GROWTH PATTERNS 94
7. DEVELOPING BRAIN IMAGING AND MAGNETIC RESONANCE SPECTROSCOPY 152
8. ANGIOGENESIS 179
SECTION 2 201
9. DEVELOPMENTAL HUMAN FETAL REACTIONS: AVOID, SQUINT, SCOWL, SNEER, AND PUCKER 203
10. BLAKE’S POUCH AND RETROCEREBELLAR CYSTS: POSTERIOR FOSSA CYSTS 219
11. DEVELOPMENTAL CENTRAL NERVOUS SYSTEM ABERRATION 238
12. CEREBRAL WHITE MATTER ABNORMALITIES 253
13. LATE FETAL AND PERINATAL BRAIN VASCULAR ABNORMALITIES AND NECROSES 285
14. FETAL AND NEONATAL INTRACRANIAL HEMORRHAGE 328
15. VENTRICULOMEGALY, LARGE HEAD, MEGALENCEPHALY, AND HYDROCEPHALUS 348
16. DEVELOPING BRAIN REACTIONS DURING CHRONIC CHILDHOOD DISEASE 380
17. CONCLUDING REMARKS 385
'This is a very unique book, one of many in the Clinics in Developmental Medicine series. Physicians and researchers who are looking for etiologies of childhood neurologic disorders with find it thought-provoking.'
Jay Goldsmith, MD, Tulane University School of Medicine
‘Pediatric neurologists, neonatologists, developmental specialists, and their trainees will all want to own a copy of this book. Although imaging modalities will change, the neuroanatomic illustrations and neuropathology will not go out of date.’
Robert Baumann, Pediatric Neurology, 2012
‘This state-of-the-art text is obviously the outcome of an impressive individual work of a well-known neuropathologoist and a neuroradiologist colleague. Yet the authors regularly compare their findings with those of others, for example, about the myelination process or the subject of angiogenesis. The descriptions and discussions are appropriately in-depth for such an important reference work and are well written, clear and comprehensible. The extensive bibliography is appropriate. Both normal and pathological conditions utilizing anatomical and radiologic comparisons are illustrated. The image quality is excellent of anatomical specimens and radiologic examinations, as are the captions and the numerous tables throughout the work. Radiologists would be especially interested in the chapter devoted to magnetic resonance spectroscopy and imaging of the developing brain.’
M. Hassan, Pediatric Radiology, 2012
‘For many neuropathologists, its histologic foundation gives this book a particularly comfortable feel, and its depth of insight will remind us about how much a hematoxylin and eosinYstained slide can reveal, that is, if it is carefully examined by someone with a well-developed (and well-trained) brain.’
Edwin S. Monuki, J Neuropathol Exp Neurol, 2012
‘Anyone with an interest in developmental neuropathology, whether from an academic, research, or a clinical diagnostic perspective, will find a wealth of information in this book. It is essential reading for any diagnostic pathologist faced with developmental brain disorders and will pique the imagination of paediatricians, anatomists and embryologists; indeed anyone with an interest in the human brain. The attention to detail, the meticulous documentation, and the thoughtful scientific approach of the authors is abundantly clear. The Developing Human Brain contains many fascinating gems of information; I would not be without it.’
Wayne Squier, Development Medicine and Child Neurology, 2012