Books

Subject: Child Neurology

Series: Clinics in Developmental Medicine

Publication date: 01/02/2010

ISBN: 9781898683667

Edition: 1st

Pages: 448

Inflammatory and Autoimmune Disorders of the Nervous System in Children

Russell Dale, Angela Vincent (Editors)

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Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable. Research into them is lagging behind adult research, but better diagnosis and often simple treatments could lead to substantial clinical benefit and reduction in long-term disability.

This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. The authors not only describe these disorders and their treatments comprehensively, helping paediatricians and paediatric neurologists to improve their understanding and recognition of the conditions, but also highlight recent and exciting developments that will be of considerable importance in the future.

  • Clinically relevant to the practising physician
  • Experts in their fields present up-to-date diagnostic and treatment approaches
  • Recent developments in basic science clearly presented

Readership

Paediatricians and paediatric neurologists. Also researchers into autoimmune neurological diseases, adult neurologists, rheumatologists and immunologists.

Clinics in Developmental Medicine No. 184-185

Russel C Dale
Russell Dale

Russell Dale is Associate Professor, Discipline of Paediatrics and Child Health, at Sydney Medical School, the University of Sydney. He is also Consultant Neurologist, co-head of the Neuroimmunology Group and Head of Movement Disorder Research at the Children’s Hospital at Westmead, Sydney, Australia.

Angela Vincent
Angela Vincent

Angela Vincent (Hon PhD Bergen) FRCPath FRCP FMedSci is Emeritus Professor of Neuroimmunology at the University of Oxford and an Emeritus Fellow of Somerville College, Oxford, UK.

Introduction and overview xiii

Russell C. Dale and Angela Vincent
1. Inflammation and autoimmunity: a nervous system perspective 1

Fabienne Brilot

2. New international definitions for central nervous system demyelination syndromes in children 14

Russell C. Dale and Silvia N. Tenembaum

3. Acute disseminated encephalomyelitis 20

Silvia N. Tenembaum and Tanuja Chitnis

4. Childhood multiple sclerosis 48

Yann Mikaeloff, Russell C. Dale and Marc Tardieu

5. Multiple sclerosis: an adults perspective 65

Gavin Giovannoni and Samuel Jackson

6. Tansverse myelitis 96

Michael Levy and Douglas Kerr

7. Optic Neuritis in Children 107

Brenda L. Banwell and Raymond Buncic

8. Sydenham Chorea 120

Francisco Cardoso

9. Paediatric Autoimmune neuropsychiatric disorders associated with Streptococcal infection 134

Tanya K. Murphy and Ana Segarra-Brechtel

10. Opsoclonus-Myoclonus Syndrome 152

Michael R. Pranzatelli and Elizabeth Tate

11. Other immune-mediated extrapyramidal movement disorders 174

Russell C. Dale

12. Postinfectious ataxia and cerebellitis 190

Deepak Gill

13. Rasmussen encephalitis 207

Christian G. Bien and Jan Bauer

14. Neuropsychiatric Manifestations of Childhood Systemic Lupus Erythematosus and Antiphospholipid syndrome 227

Liora Harel and Emily von Scheven

15. Central Nervous System Vasculitis 246

Jorina Elbers and Susanne M. Benseler

16. Macrophage activation syndromes 266

Marc Tardieu and Nizar Mahlaoui

17. Aicardi-Goutière syndrome and related disorders 275

John B.P. Stephenson and Yanick J. Crow

18. Neonatal-onset multisystem inflammatory disorder/chronic infantile neurological cutaneous syndrome 287

Simon R. Ling and P. Ian Andrews

19. Folate receptor autoimmunity in cerebral folate deficiency 302

Vincent T. Ramaekers and Edward V. Quadros

20. The Innate Immune System and Inflammatory Mechanisms in Neurodegenerative Disorders 317

Ming Lim, Mylvaganam Jeyakumar and Frances Platt

21. Glutamate receptor autoantibodies in epilepsy, systemic lupus erythematosus, and encephalitis 341

Mia Levite and Yonatan Ganor

22. Autoimmune channelopathies and other antibodyassociated neurological disorders 365

Angela Vincent and Russell C. Dale

23. Childhood autoimmune myasthenia 388

Jeremy Parr, Sandeep Jayawant, Camilla Buckley and Angela Vincent

24. Guillain-barre syndrome and chronic inflammatory demyelinating polyneuropathy in childhood 406

Monique M. Ryan, John D. Pollard, and Robert A. Ouvrier

25. Dermatomyositis and polymyositis 431

Elizabeth Stringer and Brian M. Feldman

26. Inflammatory mechanisms in genetic neuromuscular disorders 453

James G. Tidball and Michelle Wehling-Henricks

Index 479

'Many of the topics in this book will be familiar to pediatric neurologists. The emphasis on the detailed immunological basis of the diseases is edifying. However, the role of the immune system in the pathophysiology of a disease like Charcot-Marie-Tooth syndrome is a surprise. This is a worthy and helpful compendium.'

Korwyn Williams, MD, PhD, Phoenix Children's Hospital

'Overall, this book is rich in information, tables, and illustrations, and I would strongly recommend it as a useful reference on a topic for which updated reviews are always needed.'

Banu Anlar, The Lancet Neurology, 2010

'This is an international multi-author tome dealing with almost all the inflammatory and autoimmune disorders that affect children. The first chapters deal with basic immunuopathologic mechanisms and nomenclature, and the remaining predominantly with specific entities. The editors aptly relate that the diverse chapters are eclectic. To my knowledge, it is the first of its kind dealing with the subject matter. Thus, it should be a very welcome addition to the neurology literature in general, and to the child neurologist's library in particular.'

Stanley Johnson, Journal of Child Neurology, 2011

'Inflammatory and Autoimmune Disorders of the Nervous System in Children, by Russell C. Dale and Angela Vincent (Editors), is exactly the book every pediatric neurologist needs when he or she sees a child with neurological symptoms. It is well-organized and covers almost all inflammatory or immune-mediated nervous system disorders in children.'

Toshiro Hara, Brain & Development, 2011

'The publication of this book is an important landmark in the establishment of pediatric neuroimmunology as a recognized subspeciality in pediatric neurology. The book is the first to provide comprehensive coverage of all of the important pediatric neuroimmunological disorders under one cover.'

Mark Gorman, Developmental Medicine & Child Neurology