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Inflammatory and Autoimmune Disorders of the Nervous System in Children
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Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable. Research into them is lagging behind adult research, but better diagnosis and often simple treatments could lead to substantial clinical benefit and reduction in long-term disability.
This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. The authors not only describe these disorders and their treatments comprehensively, helping paediatricians and paediatric neurologists to improve their understanding and recognition of the conditions, but also highlight recent and exciting developments that will be of considerable importance in the future.
- Clinically relevant to the practising physician
- Experts in their fields present up-to-date diagnostic and treatment approaches
- Recent developments in basic science clearly presented
Readership
Paediatricians and paediatric neurologists. Also researchers into autoimmune neurological diseases, adult neurologists, rheumatologists and immunologists.
Clinics in Developmental Medicine No. 184-185
Russel C Dale
Russell Dale is Associate Professor, Discipline of Paediatrics and Child Health, at Sydney Medical School, the University of Sydney. He is also Consultant Neurologist, co-head of the Neuroimmunology Group and Head of Movement Disorder Research at the Children’s Hospital at Westmead, Sydney, Australia.
Angela Vincent
Angela Vincent (Hon PhD Bergen) FRCPath FRCP FMedSci is Emeritus Professor of Neuroimmunology at the University of Oxford and an Emeritus Fellow of Somerville College, Oxford, UK.
Introduction and overview xiii
Russell C. Dale and Angela Vincent
1. Inflammation and autoimmunity: a nervous system perspective 1
Fabienne Brilot
2. New international definitions for central nervous system demyelination syndromes in children 14
Russell C. Dale and Silvia N. Tenembaum
3. Acute disseminated encephalomyelitis 20
Silvia N. Tenembaum and Tanuja Chitnis
4. Childhood multiple sclerosis 48
Yann Mikaeloff, Russell C. Dale and Marc Tardieu
5. Multiple sclerosis: an adults perspective 65
Gavin Giovannoni and Samuel Jackson
6. Tansverse myelitis 96
Michael Levy and Douglas Kerr
7. Optic Neuritis in Children 107
Brenda L. Banwell and Raymond Buncic
8. Sydenham Chorea 120
Francisco Cardoso
9. Paediatric Autoimmune neuropsychiatric disorders associated with Streptococcal infection 134
Tanya K. Murphy and Ana Segarra-Brechtel
10. Opsoclonus-Myoclonus Syndrome 152
Michael R. Pranzatelli and Elizabeth Tate
11. Other immune-mediated extrapyramidal movement disorders 174
Russell C. Dale
12. Postinfectious ataxia and cerebellitis 190
Deepak Gill
13. Rasmussen encephalitis 207
Christian G. Bien and Jan Bauer
14. Neuropsychiatric Manifestations of Childhood Systemic Lupus Erythematosus and Antiphospholipid syndrome 227
Liora Harel and Emily von Scheven
15. Central Nervous System Vasculitis 246
Jorina Elbers and Susanne M. Benseler
16. Macrophage activation syndromes 266
Marc Tardieu and Nizar Mahlaoui
17. Aicardi-Goutière syndrome and related disorders 275
John B.P. Stephenson and Yanick J. Crow
18. Neonatal-onset multisystem inflammatory disorder/chronic infantile neurological cutaneous syndrome 287
Simon R. Ling and P. Ian Andrews
19. Folate receptor autoimmunity in cerebral folate deficiency 302
Vincent T. Ramaekers and Edward V. Quadros
20. The Innate Immune System and Inflammatory Mechanisms in Neurodegenerative Disorders 317
Ming Lim, Mylvaganam Jeyakumar and Frances Platt
21. Glutamate receptor autoantibodies in epilepsy, systemic lupus erythematosus, and encephalitis 341
Mia Levite and Yonatan Ganor
22. Autoimmune channelopathies and other antibodyassociated neurological disorders 365
Angela Vincent and Russell C. Dale
23. Childhood autoimmune myasthenia 388
Jeremy Parr, Sandeep Jayawant, Camilla Buckley and Angela Vincent
24. Guillain-barre syndrome and chronic inflammatory demyelinating polyneuropathy in childhood 406
Monique M. Ryan, John D. Pollard, and Robert A. Ouvrier
25. Dermatomyositis and polymyositis 431
Elizabeth Stringer and Brian M. Feldman
26. Inflammatory mechanisms in genetic neuromuscular disorders 453
James G. Tidball and Michelle Wehling-Henricks
Index 479
'Many of the topics in this book will be familiar to pediatric neurologists. The emphasis on the detailed immunological basis of the diseases is edifying. However, the role of the immune system in the pathophysiology of a disease like Charcot-Marie-Tooth syndrome is a surprise. This is a worthy and helpful compendium.'
Korwyn Williams, MD, PhD, Phoenix Children's Hospital
'Overall, this book is rich in information, tables, and illustrations, and I would strongly recommend it as a useful reference on a topic for which updated reviews are always needed.'
Banu Anlar, The Lancet Neurology, 2010
'This is an international multi-author tome dealing with almost all the inflammatory and autoimmune disorders that affect children. The first chapters deal with basic immunuopathologic mechanisms and nomenclature, and the remaining predominantly with specific entities. The editors aptly relate that the diverse chapters are eclectic. To my knowledge, it is the first of its kind dealing with the subject matter. Thus, it should be a very welcome addition to the neurology literature in general, and to the child neurologist's library in particular.'
Stanley Johnson, Journal of Child Neurology, 2011
'Inflammatory and Autoimmune Disorders of the Nervous System in Children, by Russell C. Dale and Angela Vincent (Editors), is exactly the book every pediatric neurologist needs when he or she sees a child with neurological symptoms. It is well-organized and covers almost all inflammatory or immune-mediated nervous system disorders in children.'
Toshiro Hara, Brain & Development, 2011
'The publication of this book is an important landmark in the establishment of pediatric neuroimmunology as a recognized subspeciality in pediatric neurology. The book is the first to provide comprehensive coverage of all of the important pediatric neuroimmunological disorders under one cover.'
Mark Gorman, Developmental Medicine & Child Neurology
