A great deal is now known about neurofibromatosis type 1, particularly as a result of the identification of its causative gene by positional cloning.
Effective treatments for its resulting cosmetic disfigurement, impaired cognitive performance and even life-threatening malignancy however sadly remain elusive.
As Dr Korf remarks in his Foreword;
‘this book’s cogent and thorough description of neurofibromatosis in children will take its place alongside other major clinical studies of the disorder. (Dr North) has tackled some of the more challenging issues, such as the basis for learning disabilities and the optimal means for early detection of optic gliomas. Her work provides a guide to the clinician and stands as a provocative challenge to the neurofibromatosis research community to further explore the basis of these problems.’
International Review of Child Neurology Series No. 1
'This book provides much useful data describing the clinical spectrum of childhood neurfibromatosis. The reader will be better informed as to the manifestations of the disorder and approach to specific complications.'
Kenneth Silver, Canadian Journal of Neurological Sciences
'This book provides a comprehensive overview of neurofibromatosis type 1 with emphasis on cognitive functions and occurence of optic glioma. The writing is clear and there is an up-to-date comprehensive chpater on genetics and description of most of the findings in NF1.'
Thomas L Slovis, Paediatric Radiology
'This book is clearly an essential addition to the shelves of all those of us that regard ourselves as neurofibromatologists. I have run a fairly low key specialist clinic for nearly a decade, I feel that there is a role for regional neurofibromatosis clinics. I suspect that also there are sufficient cases such that if each district or community paediatric service designated one paediatrician to look after all of them, the general burden of the cognitive problems (occurring in between 30% and 50% of children) so elegantly described by Dr North would become more apparent and the children given better support. This book is a must for anybody wanting to undertake this challenge and for paediatric neurologists, on whom the burden of assessing children with the more severe cognitive problems and neurological complications falls.'
Susan Huson, Archives of Disease in Childhood