Clinical Practice of Child Neurology in Infancy Course


Mac Keith Press and the European Paediatric Neurology Society present an interactive online learning course that provides authoritative advice on managing neurological disorders presenting in infancy. Completion will enable you to better support families, assess young children and work in an interdisciplinary way with other professionals and caregivers to assess, diagnose and manage neurological and neurodevelopmental problems in the first two years of life.

EACCME® accredited

EPNS member discount

To take advantage of the EPNS membership discount, email

Companion course

Our companion course Principles of Child Neurology in Infancy Course highlights the importance of clinicians’ understanding of prevention and promotion practices that support healthy development, and the challenges of diagnosis and management of common neurological conditions during infancy. Taken together these provide coverage of the entire scope of neurological problems in the first two years of life. Start your free trial of the Principles of Child Neurology in Infancy course.

To buy the companion course at a bundle discount £300 £200, just add them both to your basket and click the add discount button highlighted below.

Watch Colin Kennedy and Coriene Catsman-Berrevoets discuss the course

About the course

Clinical Practice of Child Neurology in Infancy is an up-to-date summary of current clinical practice in paediatric neurology, covers a wide range of clinical scenarios, and provides authoritative advice from distinguished experts who present an accessible, symptom-based approach to clinical problems and their management. Topics, written by experts in the field, set out:

  • Summaries of current clinical practice in paediatric neurology covering a wide range of clinical scenarios
  • Provides a symptom-based approach to clinical problems and their management
  • Includes topics covering the most recent developments in the field including stroke and sleep disorders, and included concise descriptions of the more recently described neurological disorders


1 Birth asphyxia and other acute encephalopathies in the newborn infant
• Definition
• Incidence
• Clinical neurobehavioural assessment of the newborn infant
• Clinical presentations of HIE with/without multiorgan failure
• Neuroimaging and neurophysiological investigations in HIE
• Prevention of HIE
• Follow-up and outcome after NE
• Outcome after neonatal HIE
2 Inherited metabolic encephalopathies of infancy
• Definition
• Intoxication type disorders: acute encephalopathy
• Energy deficiency
• IEM with chronic presentations
• Muscular hypotonia
• Intellectual disability with or without microcephaly
• Multisystem disease with or without dysmorphic signs
• IEM with neurodegeneration
3 Neonatal seizures
• Definitions
• Clinical approach
• Neonatal seizure syndromes
• Correlation of EEG and clinical seizures
• Common aetiologies of neonatal seizures
• Birth asphyxia
• Stroke
• CNS infections
• Rare aetiologies of neonatal seizures
• Monogenic epileptic encephalopathies
• Treatment of neonatal seizures
4 Acute encephalopathy and traumatic brain injury
• Definition
• Causes
• General principles of management
• Clinical assessment of a child with acute encephalopathy
• Specific noninfectious acute encephalopathies that may mimic infection
• TBI and inflicted TBI
• Acute metabolic encephalopathies
• Acute toxic encephalopathies
5 Stroke
• Types of stroke
6 Acute neurological illness with fever: meningitis, encephalitis, and infective space-occupying lesions
• Introduction to neurological infectious diseases
• Definitions
• Acute bacterial meningitis
• Chronic bacterial meningitis
• Fungal meningitis
• Viral (aseptic) meningitis
• Encephalitis
• Autoimmune encephalitis
• Malaria
• Infective SOLs
7 Postneonatal epileptic seizures
• Definitions
• Epileptic seizures
• Clinical approach to an infant presenting with a first seizure
• Febrile seizures
• Status epilepticus
• Epilepsies with onset in the first year of life
• Epilepsies with onset during the neonatal period or early infancy
• Epilepsies with onset in infancy
• Treatment options for epilepsy in the first year of life
8 Nonepileptic paroxysmal disorders in infancy
• Breath-holding spells (prolonged expiratory apnoea)
• Reflex anoxic seizures (or reflex asystolic syncope)
• Anoxic-epileptic seizures without epilepsy
• Tonic attacks with acutely raised intracranial pressure
• Imposed upper airways obstruction
• Alternating hemiplegia of childhood
• Hyperekplexia
• Benign neonatal sleep myoclonus
• Fejerman syndrome: shuddering, benign nonepileptic infantile spasms, benign myoclonus of early infancy
• Infantile masturbation/gratification
• Paroxysmal torticollis
9 Microcephaly, including ongenital infections
• Definition
• Measurement
• Consultation
• Primary microcephaly
• ‘Benign’ familial microcephaly
• Secondary microcephaly
• Investigations
• Management
10 Macrocephaly, including hydrocephalus and brain tumours
• Definition
• Clinical approach to assessment of head size and shape
• Megalencephaly
• Hydrocephalus
• Idiopathic (or ‘benign’) external hydrocephalus
• Craniosynostosis
• Abnormal head shape without synostosis
• Brain tumours
• Common myths about assessment of the cranium and ventricles
11 The floppy infant
• Definition
• Origin of hypotonia
• Clinical approach
• Investigations
• Treatment
• Prognosis
• Specific conditions
12 Infant sleep and behaviour
• Temperament
• Sleep regulation
• Risk factors
• Management
• The development of infant sleep
• Evaluation of infant sleep
• Behavioural insomnia of childhood
• Sleep disorders
• Breathing disorders
• Parasomnias
• Movement disorders
13 Early developmental impairment and neurological abnormalities at birth
• Definitions
• Epidemiology
• Causes of developmental impairment
• Red flag factors of potential concern
• Clinical approach
• Principles of management
• Treatment and therapy
• Neural tube defects
• Fetal alcohol spectrum disorders (FASD)
• Down syndrome
• Congenital hypothyroidism
• Specific genetic syndromes other than Down syndrome
14 Cerebral palsy
• Definition
• Clinical approach
• Management and follow-up
15 Central nervous system disorders of movement other than cerebral palsy
• Definitions
• Introduction and clinical approach
• Paroxysmal movement disorders in neonates: clinical approach
• Persistent movement disorders in neonates: clinical approach
• Paroxysmal disorders in infancy: clinical approach
• Persistent movement disorders in infants: clinical features
16 Progressive loss of skills
• Introduction
• Clinical approach
• Early regression with prominent seizures
• Inherited disorders of metabolism presenting as progressive disorders
• Other disorders which may present with loss of skills
• Rare static disorders with severe epilepsy and developmental impairment
• Management of neurodegenerative conditions
A Growth charts
B Useful resources

Colin Kennedy (Editor)

Professor Colin Kennedy

Colin Kennedy is Emeritus Professor in Neurology and Paediatrics at the University of Southampton. He studied Psychology and Medicine in Oxford and London and, as a postgraduate, in London, Southampton and Johns Hopkins Hospital, Baltimore. He was the founding paediatric neurologist and, for 25 years, clinical lead of the Southampton-based service. He is past president of the BPNA and the EPNS and works with WHO to ‘level up’ the health care of children with neurological problems across WHO Europe.

Gian Paolo Chiaffoni, Leena Haataja, Richard W Newton, Thomas Sejersen and Jane Williams (Associate Editors)

Gian Paolo Chiaffoni is Head of the Department of Pediatrics at the Conegliano and Vittorio Veneto Hospital in Conegliano, Italy.

Leena Haataja is Professor in Pediatric Neurology at the University of Helsinki and Consultant in Pediatric Neurology at Helsinki University Hospital, Children’s Hospital, and Pediatric Research Center in Helsinki, Finland.

Richard W Newton is Honorary Consultant Paediatric Neurologist at the Royal Manchester Children’s Hospital in Manchester, UK.

Thomas Sejersen is Professor and Pediatric Neurologist at the Department of Neuropediatrics at Astrid Lindgren Children’s Hospital in Stockholm, Sweden.

Jane Williams is Consultant Paediatrician, Neurodisability and Child Health at Nottingham Children’s Hospital part of Nottingham University Hospital NHS Trust in Nottingham, UK.

Full list of course contributors

Ilona Autti-Rämö

Adjunct Professor, Division of Child Neurology, University of Helsinki Children’s Hospital, Helsinki, Finland

Peter Baxter

Paediatric Neurologist, Sheffield Childrens Hospital, Sheffield, UK

Vittorio Belmonti

Child Neuropsychiatrist, IRCCS Fondazione Stella Maris, Pisa, Italy

Gian Paolo Chiaffoni

Head, Department of Pediatrics, Conegliano and Vittorio Veneto Hospital, Conegliano, Italy

Richard FM Chin

Professor in Paediatric Neurosciences and Honorary Consultant Paediatric Neurologist, The University of Edinburgh and Royal Hospital for Sick Children, Edinburgh, UK

Imti Choonara

Emeritus Professor in Child Health, University of Nottingham, Derby, UK

Giovanni Cioni

University Professor and Head, Department of Developmental Neuroscience, Stella Maris Scientific Institute and University of Pisa, Pisa, Italy

J Helen Cross

The Prince of Wales’s Chair of Childhood Epilepsy, UCL Great Ormond Street Institute of Child Health; Honorary Consultant Paediatric Neurologist, Great Ormond Street Hospital for Children NHS Trust, London, UK

Leena Haataja

Professor in Pediatric Neurology, University of Helsinki; Consultant in Pediatric Neurology, Helsinki University Hospital, Children’s Hospital, and Pediatric Research Center, Helsinki, Finland

Hans Hartmann

Consultant Paediatric Neurologist, Hannover Medical School, Clinic for Paediatric Kidney-, Liver[1]and Metabolic Diseases, and Child Neurology, Hannover, Germany

Florian Heinen

Professor of Paediatrics and Head of Department, Paediatric Neurology and Developmental Medicine, University of Munich, Hauner Children’s Hospital, Center for International Health (CIH), LMU, Munich, Germany

Helgi Hjartarson

Pediatric Neurologist, MD, Department of Neuropediatrics, Astrid Lindgren Children’s Hospital, Stockholm, Sweden

Varsine Jaladyan

Doctor, Child Neurology, ‘Arabkir’ Medical Centre & Institute of Child and Adolescent Health, Yerevan, Armenia

Harriet Joy

Consultant Neuroradiologist, Wessex Neurological Centre, University Hospital Southampton, Southampton, UK

Colin Kennedy

Professor in Neurology and Paediatrics, University of Southampton; Honorary Consultant in Paediatric Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, UK

Fenella Kirkham

Professor of Paediatric Neurology, Developmental Neurosciences Department, UCL Great Ormond Street Institute of Child Health, London, UK

Rachel Kneen

Consultant Paediatric Neurologist, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK

Rael Laugesaar

Faculty of Medicine, University of Tartu, Tartu, Estonia

Andrew L Lux

Consultant Paediatric Neurologist, Bristol Royal Hospital for Children; Honorary Senior Clinical Lecturer in Clinical Sciences, Bristol Medical School, University of Bristol, Bristol, UK

Vlatka Mejaški-Bošnjak

Pediatric Neurologist, Children’s Hospital Medical School, University of Zagreb, Zagreb, Croatia

Tuuli Metsvaht

Professor, Faculty of Medicine, University of Tartu, Tartu, Estonia

Mary Morgan

Consultant Paediatric Haematologist − retired 2016, University Hospital, Southampton, UK

Alla Nechay

Doctor, Neurology Department, Kyiv City Paediatric Hospital, Kyiv, Ukraine

Charles Newton

Professor, Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Kilifi Kenya; Department of Psychiatry, Oxford University, Oxford, UK Richard W Newton Honorary Consultant Paediatric Neurologist, Royal Manchester Children’s Hospital, Manchester, UK

Catarina Olimpio

Speciality Registrar in Clinical Genetics, Addenbrookes Hospital, Cambridge, UK

E Juulia Paavonen

Deputy Chief Physician, Child Psychiatry, Helsinki University Hospital, Helsinki Uusimaa Hospital District; Research Manager, Finnish Institute for Health and Welfare, Helsinki, Finland

Alasdair PJ Parker

Consultant Paediatric Neurologist, Addenbrooke’s Hospital; Associate Lecturer, University of Cambridge, Cambridge, UK

Barbara Plecko

University Professor; Doctor; Head of the Clinical Department of General Paediatrics, University Clinic for Paediatrics and Adolescent Medicine, Graz, Austria

Audrone Prasauskiene

Child Neurologist, Director at the Children’s Rehabilitation Hospital affiliated to the University Hospital; Professor at the Lithuanian University of Health Sciences, Kaunas, Lithuania

Kaija Puura

Professor of Child Psychiatry Tampere University; Chief Child Psychiatrist, Tampere University Hospital, Tampere, Finland

Outi Saarenpää-Heikkilä

Deputy Chief of the Unit of Pediatric Neurology, Department of Pediatrics, Tampere University Hospital, Tampere, Finland

Bernhard Schmitt

Professor of Paediatric Neurology (retired), University Children’s Hospital, Zurich, Switzerland

Maryze Schoneveld van der Linde

Owner, Patient Centered Solutions, Varsseveld, the Netherlands

Thomas Sejersen

Professor, Pediatric Neurologist, Department of Neuropediatrics, Astrid Lindgren Children’s Hospital, Stockholm, Sweden

John BP Stephenson

Honorary Professor of Paediatric Neurology, University of Glasgow and Retired Consultant Paediatric Neurologist, Fraser of Allander Neurosciences Unit, Royal Hospital for Sick Children, Glasgow, Scotland, UK

Inga Talvik

Head of the Department of Neurology and Neurorehabilitation, Tallinn Children’s Hospital, Tallinn, Estonia Tiina Talvik Professor Emeritus, Faculty of Medicine, University of Tartu, Tartu, Estonia

Meral Topcu

Professor of Pediatrics and Pediatric Neurologist, Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Daniele Trevisanuto

Associate Professor of Pediatrics, University of Padova, Padova, Italy

Brigitte Vollmer

Associate Professor of Neonatal and Paediatric Neurology, Clinical Neurosciences, Clinical and Experimental Science, Faculty of Medicine, University of Southampton; Honorary Consultant Paediatric Neurologist, Southampton Children’s Hospital, Southampton, UK

Valerie Walker

Honorary Consultant Chemical Pathologist, University Hospital, Southampton, UK

Jane Williams

Consultant Paediatrician, Neurodisability and Child Health, Nottingham Children’s Hospital, Nottingham University Hospital NHS Trust, Nottingham, UK

Geoffrey Woods

Professor of Medical Genetics, The Clinical Medical School, University of Cambridge, UK Honorary Consultant in Clinical Genetics, Addenbrookes Hospital, Cambridge, UK

Dilek Yalnizoglu

Professor of Paediatrics, Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Accessed online and hosted on a Moodle learning platform, the course is open for you to work through at your own pace for 12 months.

  • Complements your clinical training to improves knowledge and clinical practice
  • Summaries of each topic highlight key messages, common errors and when to worry
  • Interact with the material by answering reflective activities to create a digital workbook
  • Test your knowledge with a Multiple Choice Questionnaire
  • Read further with references and free access to videos and seven classic paediatric neurology text books
  • Receive a PDF certificate on completeion with 11 EACCME® credits (can be converted to AMA PRA Category 1 Credit™)
  • Estimated time to complete: 13.5 hours

Who will find this course useful?

This course will be of greatest relevance to paediatricians, neurologists, paediatric neurologists (during or after postgraduate training), and to sub-specialised paediatric neurologists seeking an update on other subspecialties.

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