Extremely Preterm Birth and its Consequences – Chapter 1: Introduction (free ebook)
This chapter is part of Extremely Preterm Birth and its Consequences
The ELGAN Study
Product Type: PDF (Sub-Section of Book)
Series: Clinics in Developmental Medicine
Edition: 1st
Publication date: December 2020
Page count: 34
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Chapter 1 – Introduction from Extremely Preterm Birth and its Consequences: The ELGAN Study
About the Complete Book
The ELGAN (Extremely Low Gestational Age Newborns) Study was the largest and most comprehensive multicentre study ever completed for this population of babies born before 28 weeks’ gestation. The authors’ presentation and exploration of the results of the research will help clinicians to prevent adverse health outcomes and promote positive health for these children. They have focused on the exposures and outcomes related to the developing brain, inflammation and infection as major risk factors for developmental adversity.
- Identifies potentially modifiable risk factors and pathways leading to a broad range of neurodevelopmental impairments in middle childhood, as well as to other conditions such as asthma, obesity, cerebral palsy and autism spectrum disorder.
- With a focus on pre-, peri-, and post-natal inflammation and the methods used to assess it.
- Covers antenatal and postnatal risk factors, then structural and functional indicators of damage to the brain.
From the Foreword
“The ELGAN Study is an important contribution and not only clarifies, but also signposts their work and future research directions … one of the most important large detailed and prospective longitudinal studies in our field.”
Neil Marlow
Professor of Neonatal Medicine, University College London
Readership
It will be a valuable and comprehensive resource for practising neonatologists, developmental paediatricians, child neurologists and psychiatrists, as well as to researchers studying population health.
Clinics in Developmental Medicine
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- Complete Book Contents
- Author Appointments
- Foreword
- Preface
- Acknowledgements
- 1. Introduction
- Alan Leviton, Olaf Dammann, T Michael O’Shea, and Nigel Paneth
- PART I Placenta and Perinatal Risk Factors
- 2. Placental Microorganisms in ELGAN with Correlation to Pregnancy Outcomes, Intrauterine Inflammation, and Postnatal and Later-life Outcomes
- Martha Scott Tomlinson and Rebecca C Fry
- 3. Correlations of Placental Histology in ELGANS With Delivery Indications, Placental Microbiology, and Childhood Morbidity
- Jonathan L Hecht
- 4. Signal Initiators of Early Preterm Birth
- Asha N Talati and Tracy A Manuck
- 5. Maternal Adiposity 43
- Jelske W van der Burg and Elizabeth T Jensen
- PART II Neonatal Exposures and Outcomes
- 6. Illness-Severity and Outcomes among Children Born Extremely Preterm
- J Wells Logan and Olaf Dammann
- 7. Bacteremia
- H Reeve Bright and Kikelomo Babata
- 8. Retinopathy of Prematurity
- Mari Holm, Deborah Van der Veen, and Olaf Dammann
- 9. Bronchopulmonary Dysplasia
- Wesley M Jackson and Matthew M Laughon
- PART III Structural Brain Disorders
- 10. Ultrasound
- Genevieve Taylor and T Michael O’Shea
- 11. Multispectral Quantitative MRI: Techniques and Preliminary Results
- Hernán Jara and T Michael O’Shea
- PART IV Function Brain Disorders
- 12. Cerebral Palsy among Children Born Extremely Preterm: The ELGAN Study
- Stephanie Watkins and T Michael O’Shea
- 13. Cognitive and Behavioral Functioning
- Lauren Bush, Megan N Scott, and Scott J Hunter
- 14. Autism, Social Impairment, and Social Communication Deficits in Children Born Prior to the 28th Week of Gestation
- Steven J Korzeniewski
- 15. Psychiatric and Behavioral Outcomes at Age 2 and 10 Years in Individuals Born Extremely Preterm
- Jean A Frazier, Hannah Zamore, and Stephen R Hooper
- 16. Concluding Chapter: Please Draw Your Own Conclusions
- Alan Leviton, Olaf Dammann, T Michael O’Shea, and Nigel Paneth
- Glossary
- Index