Book series: International Review of Child Neurology Series

This is a comprehensive framework for the care needed by children and their families following a traumatic brain injury.

From the Preface:

‘Traumatic brain injury in children and adolescents is a significant epidemiological and health problem in all countries of the world.  Severe brain injury forever alters the lives of affected children and their families. What has become clear is that there is also a ‘silent epidemic’ of mild head injury and that many children – for what is now recognized as the result of individual genetic differences and vulnerabilities of injury characteristics – are at risk for significant long-term cognitive and behavioural disabilities of varying severity. The future will hold promise for children who have had traumatic brain injury; neuroprotective strategies, advanced treatment in neurointensive settings and new rehabilitation approaches will all play a role in reducing disability. Preventive measures – with the regulatory and legislative strength of governments – hold the key to reduction in the incidence of traumatic brain injury.’

International Review of Child Neurology Series No. 9

The leukodystrophies are serious, progressive disorders of demyelination, manifesting themselves in infancy or early childhood and progressing rapidly, leading to loss of sight, hearing, speech, and ambulation, and early death.

This book is a comprehensive guide to the genetics and pathogenesis of these disorders, as well as their clinical features, diagnosis and therapy, is needed, particularly as their early identification can allow more effective treatment. Its purpose is to summarize for the reader all aspects of the inherited disorders of myelin in children and adults.

After a comprehensive overview of myelin and the role of oligodendrocytes, astrocytes and microglia in white matter disease, chapters are then devoted to individual disorders, covering their biochemical and molecular basis, genetics, pathophysiology, clinical features, diagnosis, treatment and screening. The final chapters address therapeutic approaches in leukodystrophies and present a clinical approach to diagnosing leukoencephalopathies in children and adults. The book was conceived by Hugo Moser, whose research led to major developments in the treatment of adrenoleukodystrophy, and is dedicated to him by his colleagues.

• Edited by world leaders in research on and treatment of leukodystrophy
• A comprehensive approach to the genetic disorders of myelin in children and adults
• Describes individual leukodystrophies in detail, including pathogenesis, genetics, clinical features, diagnosis and treatment.

Readership

Paediatric and adult neurologists, paediatricians, geneticists.

International Review of Child Neurology Series No. 12

Given the tremendous advances in the last five years in the understanding of acquired neonatal brain injury and in the care of affected newborn infants, this book provides a timely review for the practising neurologist, neonatologist and pediatrician.

The editors take a pragmatic approach, focusing on specific populations encountered regularly by the clinician.

They begin by addressing aspects of fetal neurology and the interpretation of fetal imaging studies. They then follow a ‘bench to bedside’ approach to acquired brain injury in the preterm and term newborn infant in the next chapters. The contributors, all internationally recognized clinician scientists, provide the clinician reader with a state-of-the art review in their area of expertise. The final section of the book address special populations and concerns, areas that are largely overlooked in existing neurology textbooks. Each of these areas has seen considerable advances in the last five years and is of increasing relevance to the neurologist and neonatologist clinician.

The comprehensive nature of each section (from basic science to acute clinical care to outcomes) should appeal broadly to scientists and allied health professionals working in neonatal neurology.

Readership

Paediatric neurologists, neonatologists, neurologists and paediatricians, clinicians in child development, child health researchers and allied health professionals (in physiotherapy, occupational therapy, speech therapy and psychology). Trainees in these areas.

International Review of Child Neurology No. 13