Disorders of Neuronal Migration

Disorders of Neuronal Migration addresses the various aspects of neuronal migration disorders in an ordered way. It will help the clinician to acquire insight as well as proficiency in diagnosis. Individual chapters describe subgroups including: – lissencephalies – subependymal heterotopia – non-lissencephalic cortical dysplasias – anomalies of the corpus callosum – hemimegalencephaly – schizencephaly – polymicrogyria and – multisystem disorders with impaired migration such as chromosomal and metabolic syndromes.

International Review of Child Neurology Series No. 5

Authors’ Appointments vii

Foreword ix

Peter G Procopis

Preface xi

Peter G Barth

1. Morphogenesis of the human cerebral cortex 1

V. S. Caviness Jr, T. Takahashi, R. S. Nowakowski and Robert Wood

2. Lissencephaly: the clinical and molecular genetic basis of diffuse malformations of neuronal migration 24

William B. Dobyns and Richard J. Leventer

3. Non-lissencephalic cortical dysplasias 58

Ruben I. Kuzniecky and Frederick Andermann

4. Periventricular gray matter heterotopia: a heterogenous group of malformations of cortical development 72

Richard J Leventer and William B Dobyns

5. Anomalies of the corpus callosum and cortical malformations 83

A. James Barkovich

6. Hemimegalencephaly 104

Laura Flores-Sarnat

7. Schizencephaly 127

Giorgio Battaglia and Tiziana Granata

8. Syndromic cortical dysplasias: a review 135

Raoul CM Hennekam and Peter G Barth

9. Polymicrogyria: role of the excitotoxic damage 170

Pierre Gressens, A James Barkovich and Philippe Evrard

10. Fetal disruption as a cause of neuronal migration defects, 182

Peter G Barth

Index 195