Acquired Brain Injury in the Fetus and Newborn – Chapter 11: Imaging Term Infants with Suspected Hypoxic–Ischemic Encephalopathy (ebook)


Chapter 11 – Imaging Term Infants with Suspected Hypoxic–Ischemic Encephalopathy

Neonatal encephalopathy is a term used to describe ‘a clinically defined syndrome of disturbed neurological function in the earliest days of life in the term infant’; it occurs in 1 to 6 per 1000 live births and is a major cause of morbidity and mortality. This chapter will focus on hypoxia–ischemia, the most common cause of this condition. We will provide a conceptual framework of neonatal encephalopathy and hypoxic–ischemic brain injury based broadly on pathophysiologic processes. This perspective clarifies how, when, and what imaging should be used to establish a diagnosis, determine the type or mechanism of injury, and assist with prognosis. We will provide a discussion of the imaging findings along with some suggestions to make this task less daunting. Finally, we will discuss the potential role of quantitative magnetic resonance imaging (MRI) tools in predicting outcomes and evaluating early interventional strategies such as cooling.

About the book

Given the tremendous advances in the last five years in the understanding of acquired neonatal brain injury and in the care of affected newborn infants, this book provides a timely review for the practising neurologist, neonatologist and pediatrician. The editors take a pragmatic approach, focusing on specific populations encountered regularly by the clinician. They begin by addressing aspects of fetal neurology and the interpretation of fetal imaging studies. They then follow a ‘bench to bedside‚’ approach to acquired brain injury in the preterm and term newborn infant in the next chapters. The contributors, all internationally recognized clinician scientists, provide the clinician reader with a state-of-the art review in their area of expertise. The final section of the book address special populations and concerns, areas that are largely overlooked in existing neurology textbooks. Each of these areas has seen considerable advances in the last five years and is of increasing relevance to the neurologist and neonatologist clinician. The comprehensive nature of each section (from basic science to acute clinical care to outcomes) should appeal broadly to scientists and allied health professionals working in neonatal neurology.

Readership: Paediatric neurologists, neonatologists, neurologists and paediatricians, clinicians in child development, child health researchers and allied health professionals (in physiotherapy, occupational therapy, speech therapy and psychology).† Trainees in these areas.

International Reviews of Child Neurology Series No. 13