Acquired Brain Injury in the Fetus and Newborn – Chapter 9: Mechanisms of Brain Neurodegeneration in the Term Infant (ebook)


Chapter 9 – Mechanisms of Brain Neurodegeneration in the Term Infant

Neural cell loss is a feature of acquired neurologic injury. Selective neuronal loss occurs after acute neurologic insults such as stroke, cardiac arrest, and trauma. Striking examples of selective vulnerability are basal ganglia and somatosensory system degeneration after perinatal hypoxic–ischemic insults and motor neuron degeneration after spinal cord trauma or brachial plexus avulsion (brachial plexus birth palsy). Systemic asphyxia resulting from a disruption in placental gas exchange occurs perinatally in two to four infants per 1000 term infants.

About the book

Given the tremendous advances in the last five years in the understanding of acquired neonatal brain injury and in the care of affected newborn infants, this book provides a timely review for the practising neurologist, neonatologist and pediatrician. The editors take a pragmatic approach, focusing on specific populations encountered regularly by the clinician. They begin by addressing aspects of fetal neurology and the interpretation of fetal imaging studies. They then follow a ‘bench to bedside‚’ approach to acquired brain injury in the preterm and term newborn infant in the next chapters. The contributors, all internationally recognized clinician scientists, provide the clinician reader with a state-of-the art review in their area of expertise. The final section of the book address special populations and concerns, areas that are largely overlooked in existing neurology textbooks. Each of these areas has seen considerable advances in the last five years and is of increasing relevance to the neurologist and neonatologist clinician. The comprehensive nature of each section (from basic science to acute clinical care to outcomes) should appeal broadly to scientists and allied health professionals working in neonatal neurology.

Readership: Paediatric neurologists, neonatologists, neurologists and paediatricians, clinicians in child development, child health researchers and allied health professionals (in physiotherapy, occupational therapy, speech therapy and psychology).† Trainees in these areas.

International Reviews of Child Neurology Series No. 13