Cerebellar Disorders in Children – Chapter 37: Acute Inflammatory Diseases of the Cerebellum (ebook)

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Chapter 37 – Acute Inflammatory Diseases of the Cerebellum

Marc Tardieu

Acute ataxia may be the consequence of an inflammatory reaction within the central nervous system (CNS). In this chapter, after a short overview on neuroimmunological aspects, the most classic benign acute inflammatory cerebellar ataxia will be reviewed, followed by a discussion of more severe forms. Acute cerebellar ataxia is sometimes differentiated, in reviews and chapters, from acute cerebellitis, the latter being more severe (Gill 2010). In this chapter the two terms are considered as equivalent with benign and severe forms, acute cerebellar ataxia being a clinical description and acute cerebellitis referring to the pathophysiology. In the later section, the autoimmune diseases, which may start as an acute infl ammatory cerebellar ataxia but are usually relapsing, will be reviewed, followed by a discussion of differential diagnosis. The four chapters in Part 8: Acute Ataxia provide a detailed overview of the causes and management of acute ataxia.

Please note that Chapters 36-39 are also available in Part 8: Acute Ataxia.

About the Complete Book:

This clinically orientated text by an international group of experts is the first definitive reference book on disorders of the cerebellum in children. It presents a wealth of practical clinical experience backed up by a strong scientific basis for the information and guidance given. The first part sets out the theoretical underpinnings of cerebellar disorders. This is followed by sections on clinical conditions grouped according to common characteristics such as aetiology and symptomatology. The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis, and management and treatment. This book will be an invaluable resource for all those caring for children affected by cerebellar disorders, including malformations, genetic and metabolic disorders, acquired cerebellar damage, vascular disorders and acute ataxias. This comprehensive reference text on cerebellar disorders in children includes chapters on cerebellar development, prenatal cerebellar imaging, imaging of the posterior fossa, with coverage of a broad range of malformations, genetic and metabolic disorders involving the cerebellum, prenatal cerebellar disruptions (as related to prematurity), vascular disorders, tumors and paraneoplastic syndromes, as well as acute ataxia and trauma to the posterior fossa. Numerous checklists are provided to assist in the differential diagnosis of clinical signs and neuroimaging findings.

Readership 
Paediatric neurologists, paediatricians, neurologists, developmental paediatricians, neuroimaging specialists, geneticists, neonatologists

Clinics in Developmental Medicine No. 191-192