Cerebellar Disorders in Children – Chapter 31: Cerebellar Injury in the Preterm Infant (ebook)


Chapter 31 – Cerebellar Injury in the Preterm Infant

Catherine Limperopoulos

Preterm birth is associated with a high risk for brain injury and extensive long-term neurodevelopmental disability. Because improved survival and the increased sensitivity and availability of advanced neuroimaging techniques in the critically ill neonate have forced a re-evaluation of preterm-related brain injury, our understanding of such injury and its long-term sequelae has changed dramatically.  This chapter will begin by providing a brief overview of cerebellar development, followed by a discussion of the developmental vulnerability of the premature cerebellum. The incidence, risk factors, and impact of preterm birth on cerebellar and cerebral development are then examined. Finally, the functional consequences of cerebellar injury in ex-preterm survivors, and the role of early-life cerebellar injury in cognitive-affect disturbances, are explored.

Please note that Chapters 30 and 31 are also available in Part 6: Cerebellar Disruptions.

About the Complete Book:

This clinically orientated text by an international group of experts is the first definitive reference book on disorders of the cerebellum in children. It presents a wealth of practical clinical experience backed up by a strong scientific basis for the information and guidance given. The first part sets out the theoretical underpinnings of cerebellar disorders. This is followed by sections on clinical conditions grouped according to common characteristics such as aetiology and symptomatology. The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis, and management and treatment. This book will be an invaluable resource for all those caring for children affected by cerebellar disorders, including malformations, genetic and metabolic disorders, acquired cerebellar damage, vascular disorders and acute ataxias. This comprehensive reference text on cerebellar disorders in children includes chapters on cerebellar development, prenatal cerebellar imaging, imaging of the posterior fossa, with coverage of a broad range of malformations, genetic and metabolic disorders involving the cerebellum, prenatal cerebellar disruptions (as related to prematurity), vascular disorders, tumors and paraneoplastic syndromes, as well as acute ataxia and trauma to the posterior fossa. Numerous checklists are provided to assist in the differential diagnosis of clinical signs and neuroimaging findings.

Paediatric neurologists, paediatricians, neurologists, developmental paediatricians, neuroimaging specialists, geneticists, neonatologists

Clinics in Developmental Medicine No. 191-192