Myasthenia in Children – Chapter 1: The Neuromuscular Junction (free ebook)


Chapter 1 – The Neuromuscular Junction by Pedro M Rodríguez Cruz and David Beeson from Myasthenia in Children

The neuromuscular junction (NMJ) is a highly specialised synapse between a motor neuron and a muscle fibre, which is essential for neuromuscular transmission. In this chapter, the most fundamental aspects of the NMJ organisation, structure and physiology biology, and physiology will be reviewed. This will provide the background to understanding the physiopathology and clinical manifestations of myasthenic disorders, either autoimmune (myasthenia gravis) or genetic (congenital myasthenic syndromes).

About the Complete Book

Myasthenia is a rare, but underdiagnosed and sometimes life-threatening disorder in children. There are no guidelines for diagnosing and managing these children, especially those with congenital myasthenia, a more recently recognised genetic condition, but there have been significant developments in identification and treatment of myasthenia in recent years. This book will help clinicians and families of children with this rare condition direct management effectively.

Myasthenia in Children describes the various genotypes and phenotypes of congenital myasthenic syndromes, their clinical features and management. Autoimmune myasthenia gravis and newly recognised myopathies with neuromuscular transmission defects are also covered. The book includes a client perspective and is full of practical tips from carers, service users and therapists with a broad multi-disciplinary treatment approach. This book will guide future holistic management of this rare but life changing condition for some children and their families.

  • Only book dedicated to this rare condition in children
  • Includes the latest developments on congenital myasthenia, a newly recognised condition
  • Uses a holistic, multi-disciplinary therapeutic approach to achieve best outcomes for children with this condition
  • Features the very latest treatment approaches
  • Includes practical management information for families and young persons with this condition, with one chapter written by the family of a child with myasthenia

Paediatricians, Paediatric neurologists, and allied health professionals, including physiotherapists, occupational therapists, psychologists and specialist nurses.

Why not?

Clinics in Developmental Medicine