Cerebellar Disorders in Children – Chapter 5: Prenatal Cerebellar Imaging (ebook)


Chapter 5 – Prenatal Cerebellar Imaging

Daniel A. Doherty and Deborah Levine

This chapter focuses on prenatal imaging of the posterior fossa and the relationship between prenatal imaging findings and postnatal outcomes. Over the past 25 years, prenatal imaging has improved remarkably, allowing the detailed visualization of brain anatomy by ultrasound and MRI. Despite these advances, little systematic data exist describing postnatal outcomes in fetuses with abnormal posterior fossa imaging. Accurate imaging data correlated with postnatal outcome is critical, since this information is often used to decide whether to continue or terminate a pregnancy. In addition to the inherent limitations in imaging the fetal brain, existing outcome studies suffer from diverse case definitions, small numbers, short duration of follow-up, retrospective study design and lack of standardized neurodevelopmental assessments. Nonetheless, it is essential to provide the most accurate information possible to support pregnancy decision-making and/or preparation for the birth of an affected child.

Please note that Chapters 5 and 6 are also available in Part 3: Imaging of the Cerebellum.

About the Complete Book:

This clinically orientated text by an international group of experts is the first definitive reference book on disorders of the cerebellum in children. It presents a wealth of practical clinical experience backed up by a strong scientific basis for the information and guidance given. The first part sets out the theoretical underpinnings of cerebellar disorders. This is followed by sections on clinical conditions grouped according to common characteristics such as aetiology and symptomatology. The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis, and management and treatment. This book will be an invaluable resource for all those caring for children affected by cerebellar disorders, including malformations, genetic and metabolic disorders, acquired cerebellar damage, vascular disorders and acute ataxias. This comprehensive reference text on cerebellar disorders in children includes chapters on cerebellar development, prenatal cerebellar imaging, imaging of the posterior fossa, with coverage of a broad range of malformations, genetic and metabolic disorders involving the cerebellum, prenatal cerebellar disruptions (as related to prematurity), vascular disorders, tumors and paraneoplastic syndromes, as well as acute ataxia and trauma to the posterior fossa. Numerous checklists are provided to assist in the differential diagnosis of clinical signs and neuroimaging findings.

Paediatric neurologists, paediatricians, neurologists, developmental paediatricians, neuroimaging specialists, geneticists, neonatologists

Clinics in Developmental Medicine No. 191-192