Cerebral Palsy: Science and Clinical Practice – Chapter 10: Pathways Involving Bilirubin and Other Brain-Injuring Agents (ebook)


Chapter 10 of the book – Pathways Involving Bilirubin and Other Brain-Injuring Agents

Dora Brites and Vinod K Bhutani

Perinatal brain injury due to certain endogenous and exogenous neurotoxins can complicate one of the most vulnerable phases of an individual’s life after birth. These agents, by breaching the blood–brain barrier (BBB), can cause subtle or acute manifestations that can progress to neonatal/childhood mortality or lead to chronic sequelae that include cerebral palsy (CP). The most frequently encountered source of endogenous neurotoxin is bilirubin, known to cause a specific form of brain damage called kernicterus when in high levels.

About the complete book

This landmark title considers all aspects of cerebral palsy from the causes to clinical problems and their implications for individuals. An international team of experts provides clinicians and researchers with key information on the mechanisms underlying impairments in movement, development, cognition, communication, vision, feeding, behaviour, sexuality, and musculoskeletal deformities.  They present a wide range of person-centred assessment approaches, including clinical evaluation, measurement scales, neuroimaging and gait analysis. The principles of multi-disciplinary management are presented, in terms of therapist intervention, medication and surgery. The perspective of the book spans the lifelong course of cerebral palsy, taking into account worldwide differences in socio-economic and cultural factors. Many chapters are illustrated with clinical vignettes enabling direct translation into practice. Full integrated colour, with extensive cross-referencing make this a highly attractive and useful reference.

Readership: Paediatric neurologists, developmental paediatricians, rehabilitation doctors, orthopaedic surgeons, child psychiatrists, physiotherapists speech and language therapists psychologists, occupational therapists and other health and educational professionals.

Clinics in Developmental Medicine Series.