Cognition and Behaviour in Childhood Epilepsy – Chapter 13: The Epileptic Syndromes with Continuous Spikes and Waves during Slow-Wave Sleep (ebook)

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Chapter 13 – The Epileptic Syndromes with Continuous Spikes and Waves during Slow-Wave Sleep

In 1957, Landau and Kleffner (1957) reported children with normal early language development who became aphasic after the onset of epileptic seizures and had bilateral temporal interictal epileptiform discharges (IEDs) on EEG. The authors suspected that persistent convulsive discharges resulted in the functional ablation of brain areas concerned with linguistic communication. The language disturbance was further characterized as auditory verbal agnosia, that is, the inability to decode phonemes despite intact peripheral hearing mechanisms, leading to a severe expressive and receptive verbal deficit. Observations of language regression without clinical seizures were further reported. Longitudinal follow-up of these children showed that the seizures as well as the EEG abnormalities remit at adolescence. The Landau–Kleffner syndrome (LKS) was recognized by the International League Against Epilepsy (ILAE) as synonymous with acquired epileptic aphasia to be classified among the epilepsies and syndromes of childhood undetermined whether focal or generalized.

About the book

For many parents, cognitive and behavioral comorbidities, such as ADHD, autism and intellectual disability, are the real burden of childhood epilepsy. This title offers concrete guidance and treatment strategies for childhood epilepsy in general, and for the comorbidities associated with each epilepsy syndrome and their pathophysiology. The book is written by experts in the field with an important clinical experience, while chapters by clinical neuropsychologists provide a strong theoretical background.

Readership: Epileptologists, Paediatric Neurologists, Paediatricians and Neuropsychologists.