Neuroendocrine Disorders in Children – Chapter 10: Genetic Childhood Obesity Syndromes (ebook)


Chapter 10 – Genetic Childhood Obesity Syndromes

Traditionally, patients affected by genetic forms of obesity were identified as a result of their association with developmental delay, dysmorphic features and/or other developmental abnormalities, that is, a pattern of clinical features which represented a recognisable syndrome. However, the identification of genetic disorders that disrupt the hypothalamic leptin-melanocortin signalling pathway has led to the recognition that obesity is the predominant presenting feature in a significant subset of individuals. Based on case series of patients with genetic obesity syndromes, childhood onset of obesity (before the age of 10 years) is a consistent feature. For purposes of clinical assessment, it remains useful to categorise the genetic obesity syndromes as those with dysmorphism and/or developmental delay and those without these features; however, in some cases the spectrum of clinical features can be quite variable.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.