Neuroendocrine Disorders in Children – Chapter 12: Late Effects of Cancer and its Treatments on the Neuroendocrine System (ebook)


Chapter 12 – Late Effects of Cancer and its Treatments on the Neuroendocrine System

Endocrine complications can affect between 20% and 50% of childhood cancer survivors and often occur as therapy-related late effects. Individuals with central nervous system (CNS) tumours and those whose hypothalamus and/or pituitary was exposed to surgery or radiation are particularly at risk of hypothalamic and pituitary dysfunction. Tumoural expansion, surgical procedures and radiotherapy can all be associated with a variety of neuroendocrine abnormalities including both diminished and excessive hormone secretion. Hypothalamic injury can also impact metabolism and appetite regulation, which in turn can significantly affect body composition.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.