Neuroendocrine Disorders in Children – Chapter 14: The Hypothalamo-Pituitary-Adrenal Axis and its Regulation (ebook)


Chapter 14 – The Hypothalamo-Pituitary-Adrenal Axis and its Regulation

The hypothalamic-pituitary-adrenal (HPA) axis regulates production of glucocorticoids and adrenal androgens. This regulation is essential for homeostasis and adaptation to environmental changes with appropriate metabolic, immune, behavioural and neuromodulatory responses. The axis consists of three major levels; in the hypothalamus, corticotrophin-releasing hormone (CRH) is synthesised. CRH stimulates the production of adrenocorticotrophic hormone (ACTH) by the anterior pituitary. ACTH subsequently stimulates the adrenal cortex to produce cortisol and adrenal androgens. Cortisol plays a role in the stress response as well as exerting negative feedback on the production of CRH and ACTH.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.