Neuroendocrine Disorders in Children – Chapter 17: Cushing Disease: Diagnosis and Management (ebook)


Chapter 17 – Cushing Disease: Diagnosis and Management

Cushing syndrome is a clinical syndrome, which comprises many symptoms and signs reflecting excessive circulating glucocorticoid concentrations. It is very rare in childhood and adolescence. The incidence of paediatric-onset Cushing syndrome is estimated as 10% of the adult Cushing syndrome prevalence, i.e. ~0.5 new cases/million/year. Cushing syndrome within the paediatric age range can be classified into two groups: adrenocorticotrophic hormone (ACTH)-independent and ACTH-dependent causes. Iatrogenic exogenous glucocorticoid administration remains the most common cause in paediatric as well as adult patients with Cushing syndrome. These patients are rarely referred for endocrine review and therefore this chapter will not discuss iatrogenic Cushing syndrome further.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.