Neuroendocrine Disorders in Children – Chapter 18: The Hypothalamic-Pituitary-Gonadal Axis (ebook)


Chapter 18 – The Hypothalamic-Pituitary-Gonadal Axis

Mammalian reproduction is under the tightly controlled regulation of a three-tiered body axis comprising gonadotrophin-releasing hormone (GnRH) neurons, located in the hypothalamus, the gonadotropin-secreting cells of the adenohypophysis and their respective target organs, the ovaries or testes, making up the hypothalamo-pituitary-gonadal (HPG) axis. In the male, the axis is under classic negative feedback control from testicular steroids and inhibin, whereas in the female, both negative and positive feedback loops operate.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.