Neuroendocrine Disorders in Children – Chapter 2: Disorders of the Hypothalamo-Pituitary-Somatotroph Axis Leading to Growth Failure (ebook)


Chapter 2 – Disorders of the Hypothalamo-Pituitary-Somatotroph Axis Leading to Growth Failure

Short stature is the commonest reason for referral to the paediatric endocrine clinic; the diagnostic approach to an abnormal growth pattern requires evaluation for underlying illness, skeletal defects or syndromes, central nervous system abnormalities and genetic defects (Wit et al. 2011). Growth hormone, secreted by the somatotroph cells of the anterior pituitary gland, is a major regulator of growth and metabolism. Congenital or acquired disorders affecting the growth hormone–insulin-like growth factor-1 (IGF-1) axis manifest primarily as growth failure. Genetic defects may affect any part of this axis including the development of somatotrophs; the control, production and secretion of growth hormone (manifesting as growth hormone deficiency [GHD]) or its action on peripheral tissues; and the synthesis of IGF-1 and its downstream signalling (manifesting as growth hormone insensitivity or resistance).

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed. Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.

Read the full book review by Ieuan Hughes published in DMCN.