Neuroendocrine Disorders in Children – Chapter 20: Precocious Puberty (ebook)


Chapter 20 – Precocious Puberty

Premature sexual maturation is a frequent cause for referral in paediatric endocrinology. Although clinical evaluation will suffice to reassure the patient and family in a majority of cases, premature sexual maturation can reveal severe conditions and needs a thorough evaluation to identify its cause and potential for progression, in order to propose an appropriate treatment if needed. Most cases of precocious puberty result from the early activation of the gonadotropin-releasing hormone (GnRH) axis and the underlying mechanism is poorly understood. Peripheral or gonadotropin-independent forms of precocious puberty are rare, have been described in detail elsewhere and will not be described extensively in this chapter. Long-acting GnRH agonists are efficient and widely used in the treatment of central precocious puberty but questions remain regarding their optimal use. Among the several ongoing controversial issues in the area are the definition of normal pubertal development and the role of environmental disruptors.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.