Neuroendocrine Disorders in Children – Chapter 21: Psychological and Behavioural Consequences of Gonadal Hormone Abnormality During Early Development (ebook)


Chapter 21 – Psychological and Behavioural Consequences of Gonadal Hormone Abnormality During Early Development

Gonadal steroids play a central role in physical sexual differentiation, as well as in sexual differentiation of behaviour and the brain. Experimental research in animals initially established the role of androgens and oestrogens in neurobehavioural development, and evidence from individuals with clinical conditions involving early hormone abnormalities has confirmed some similar influences in humans. These clinical conditions include classic congenital adrenal hyperplasia (CCAH), complete androgen insensitivity syndrome (CAIS), Turner syndrome, androgen biosynthetic deficiencies and other conditions causing abnormal penile development. This chapter will first summarise briefly the main points that have emerged from experiments where gonadal hormones have been manipulated in non-human species, and will then detail the evidence from studies of human clinical conditions that suggest similar effects in human beings. Finally, it will outline some implications for clinical care of individuals who experience gonadal steroid abnormalities early in life.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.