Neuroendocrine Disorders in Children – Chapter 23: Central Actions of Insulin (ebook)


Chapter 23 – Central Actions of Insulin

Insulin is the quintessential hormone of plenty, its release tightly coupled to the ingestion and absorption of nutrients, and its actions serving to orchestrate the body’s response to availability of anabolic substrates. Specifically, insulin activates intracellular signalling pathways required for uptake, utilisation and storage of glucose, amino acids and fatty acids, while simultaneously inhibiting the catabolic processes involved in the breakdown of glycogen, fat and protein. Decades of research have focused on uncovering the intricate insulin signalling network in the liver, skeletal muscle and adipose tissue, which have long been regarded as the canonical insulin-responsive tissues essential for the systemic actions of insulin.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.