Neuroendocrine Disorders in Children – Chapter 3: The Effect of Growth Hormone on the Brain (ebook)


Chapter 3 – The Effect of Growth Hormone on the Brain

Growth hormone is recognised as one of the major hormonal compounds produced by somatotrophs in the anterior pituitary. The human variant of growth hormone consists of a single polypeptide chain of 191 amino acids. Its secretion is controlled by the hypothalamic hormones, growth hormone–releasing hormone (GHRH) and somatostatin. Whereas GHRH stimulates its release, somatostatin acts an inhibitor of growth hormone secretion (GHS). Several other peptides known to elicit stimulatory effects on growth hormone release, for example, ghrelin, have also been described. Growth hormone regulates its own secretion through interactions with catecholamines in the median eminence of the hypothalamus.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed. Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.

Read the full book review by Ieuan Hughes published in DMCN.