Neuroendocrine Disorders in Children – Chapter 4: Impact of Disorders of the Growth Hormone–IGF-1 Axis on Neurological Function (ebook)
Chapter 4 – Impact of Disorders of the Growth Hormone–IGF-1 Axis on Neurological Function
Aristotle first suggested that there may be an association between ‘dwarfism’ and impaired cognition. Evidence is accumulating that the growth hormone axis plays an important role in normal brain growth and development, with an ongoing role in determining childhood and adult cognitive function. There is also evidence to suggest that insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) deficiency, such as that found in children and adults with growth hormone deficiency (GHD), are associated with cognitive deficits and changes in brain structure, with cognitive improvements seen following growth hormone treatment.
About the book
Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children. These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.
Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed. Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.
Read the full book review by Ieuan Hughes published in DMCN.