Neuroendocrine Disorders in Children – Chapter 8: Impact of Thyroid Disorders on Neurological Function (ebook)


Chapter 8 – Impact of Thyroid Disorders on Neurological Function

Thyroid hormone is essential for normal brain development and subsequent brain function. During gestation and infancy, thyroid hormone serves to regulate transcription of critical genes for essential neurobiological processes such as neurogenesis and myelination and it accomplishes this via regionally specific thyroid hormone receptors with unique ontogenetic schedules. Subsequently, thyroid hormone plays a critical role in neurotransmission and associated cognitive activities (e.g. attention, speed of processing). These various effects appear to differ in developing versus mature brain. Consequently, to ensure normal neurologic and neuropsychologic abilities, it is necessary to maintain adequate levels of thyroid hormone throughout development. Since paediatric hypothyroidism and thyrotoxicosis each involve abnormal concentrations of thyroid hormone, it is not surprising that children affected by these disorders show cognitive and behavioural abnormalities. In this chapter, I will review the current state of knowledge on outcome following both disorders, although the evidence is far greater for hypothyroid than for hyperthyroid childhood disorders.

About the book

Impairments in the interaction between the central nervous system and the endocrine system can lead to a number of disorders in children.  These include type 1 diabetes, growth disorders, adrenal thyroid and pituitary problems, Addison’s disease and Cushing syndrome, among others.

Neuroendocrine Disorders in Children provides a comprehensive examination of paediatric and adolescent disorders focusing on the basic science and its clinical relevance. Complex issues are discussed in an easy-to-follow manner and the latest developments in the area are reviewed.

Read the full book review by Ieuan Hughes published in DMCN.

Readership: paediatric endocrinologists, paediatric and adult neurologists and trainee paediatricians.